The presence of BK virus (BKV) and JC virus (JCV) in autopsy materials (placenta, brain, and kidney) of aborted fetuses was investigated by PCR using two sets of primers, specific for the regulatory region (RR) and for the capsid protein VP1, respectively. The RR of BKV was detected in 12 samples of placenta and brain and in nine samples of kidney obtained from 15 fetuses. Out of the 12 positive cases, four placentas, one brain, and three kidney samples also showed the presence of BKV DNA in the VP1 region. Of 12 placentas from a control group with a normal pregnancy outcome, the RR of BKV was detected in six samples, four of which were also positive for the VP1 region. None of the samples from either group was positive for the RR of JCV. In two cases, the nucleotide sequence of the BK RR demonstrated that the viruses isolated from maternal and fetal tissues showed a high homology with one another and had a characteristic deletion of the R63 box compared to the archetype strain. The results indicate that BKV may be transmitted vertically.

Transplacental transmission of human polyomavirus BK / Pietropaolo, Valeria Antonietta; DI TARANTO, C.; Degener, Anna Marta; Jin, L.; Sinibaldi, Laura; Baiocchini, A.; Melis, Marco; Orsi, Nicola. - In: JOURNAL OF MEDICAL VIROLOGY. - ISSN 0146-6615. - STAMPA. - 56:(1998), pp. 372-376. [10.1002/(SICI)1096-9071(199812)56:4<372::AID-JMV14>3.0.CO;2-4]

Transplacental transmission of human polyomavirus BK

PIETROPAOLO, Valeria Antonietta;DEGENER, Anna Marta;SINIBALDI, Laura;MELIS, Marco;ORSI, Nicola
1998

Abstract

The presence of BK virus (BKV) and JC virus (JCV) in autopsy materials (placenta, brain, and kidney) of aborted fetuses was investigated by PCR using two sets of primers, specific for the regulatory region (RR) and for the capsid protein VP1, respectively. The RR of BKV was detected in 12 samples of placenta and brain and in nine samples of kidney obtained from 15 fetuses. Out of the 12 positive cases, four placentas, one brain, and three kidney samples also showed the presence of BKV DNA in the VP1 region. Of 12 placentas from a control group with a normal pregnancy outcome, the RR of BKV was detected in six samples, four of which were also positive for the VP1 region. None of the samples from either group was positive for the RR of JCV. In two cases, the nucleotide sequence of the BK RR demonstrated that the viruses isolated from maternal and fetal tissues showed a high homology with one another and had a characteristic deletion of the R63 box compared to the archetype strain. The results indicate that BKV may be transmitted vertically.
1998
BK virus (BKV) and JC virus (JCV); aborted fetuses; PCR; Transplacental transmission
01 Pubblicazione su rivista::01a Articolo in rivista
Transplacental transmission of human polyomavirus BK / Pietropaolo, Valeria Antonietta; DI TARANTO, C.; Degener, Anna Marta; Jin, L.; Sinibaldi, Laura; Baiocchini, A.; Melis, Marco; Orsi, Nicola. - In: JOURNAL OF MEDICAL VIROLOGY. - ISSN 0146-6615. - STAMPA. - 56:(1998), pp. 372-376. [10.1002/(SICI)1096-9071(199812)56:4<372::AID-JMV14>3.0.CO;2-4]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/242336
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 15
  • Scopus 83
  • ???jsp.display-item.citation.isi??? 75
social impact