Hepatitis C virus (HCV) infection may be complicated by non-Hodgkin's lymphoma. We describe eight cases of B-cell extranodal non-Hodgkin's lymphoma occurring during the course of chronic HCV-related hepatic disease ao iv-grade of mucosa-associated lymphoid tissue [MALT]-type; diffuse large cell; Burkitt; diffuse small cell. Some were localized to the liver (2), liver and spleen (1), spleen (1), peritoneal cavity (1), parotid gland (1); others manifested in the nasopharynx (1) and eyelid (1) but were accompanied by nodal disease. Four lymphomatous specimens available for molecular analysis exhibited clonal immunoglobulin gene rearrangements, lacked bcl-2 bcl-6, c-myc genes and p53 alterations, and did not contain replicative intermediate HCV RNA, as documented by a strand-specific reverse transcriptase-polymerase chain reaction. Low levels of positive-strand HCV RNA were detected in a single hepatic lymphoma, suggesting the presence of the virus in residual hepatocytes. The antigen-driven properties of HCV-associated B-cell malignant neoplasms may be considered for hepatic MALT-type lymphoma which probably originated from lymphoid tissue acquired during long-standing HCV infection.

Extranodal lymphomas associated with hepatitis C virus infection / Ascoli, Valeria; F., Lo Coco; Artini, Marco; Levrero, Massimo; Martelli, Maurizio; F., Negro. - In: AMERICAN JOURNAL OF CLINICAL PATHOLOGY. - ISSN 0002-9173. - 109:5(1998), pp. 600-609.

Extranodal lymphomas associated with hepatitis C virus infection

ASCOLI, Valeria;ARTINI, Marco;LEVRERO, Massimo;MARTELLI, Maurizio;
1998

Abstract

Hepatitis C virus (HCV) infection may be complicated by non-Hodgkin's lymphoma. We describe eight cases of B-cell extranodal non-Hodgkin's lymphoma occurring during the course of chronic HCV-related hepatic disease ao iv-grade of mucosa-associated lymphoid tissue [MALT]-type; diffuse large cell; Burkitt; diffuse small cell. Some were localized to the liver (2), liver and spleen (1), spleen (1), peritoneal cavity (1), parotid gland (1); others manifested in the nasopharynx (1) and eyelid (1) but were accompanied by nodal disease. Four lymphomatous specimens available for molecular analysis exhibited clonal immunoglobulin gene rearrangements, lacked bcl-2 bcl-6, c-myc genes and p53 alterations, and did not contain replicative intermediate HCV RNA, as documented by a strand-specific reverse transcriptase-polymerase chain reaction. Low levels of positive-strand HCV RNA were detected in a single hepatic lymphoma, suggesting the presence of the virus in residual hepatocytes. The antigen-driven properties of HCV-associated B-cell malignant neoplasms may be considered for hepatic MALT-type lymphoma which probably originated from lymphoid tissue acquired during long-standing HCV infection.
1998
b cell; hcv genotype; immunoglobulin heavy-chain rearrangement; liver; lymphoma; strand-specific reverse transcriptase-polymerase chain reaction [rt- pcr]; strand-specific reverse transcriptase-polymerase chain reaction [rt-pcr]
01 Pubblicazione su rivista::01a Articolo in rivista
Extranodal lymphomas associated with hepatitis C virus infection / Ascoli, Valeria; F., Lo Coco; Artini, Marco; Levrero, Massimo; Martelli, Maurizio; F., Negro. - In: AMERICAN JOURNAL OF CLINICAL PATHOLOGY. - ISSN 0002-9173. - 109:5(1998), pp. 600-609.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/242250
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