The influence of iron on the entry of Listeria monocytogenes into Caco-2 cells was studied. Iron availability was found to modify the surface hydrophobicity and protein profile of L. monocytogenes, with the result that cell invasion strongly increased upon bacterial growth in iron-rich medium. The enhanced invasive capability of iron-overloaded L. monocytogenes cells correlates to the higher-level expression of the inlAB virulence genes, which were positively iron regulated at the transcriptional level.
Iron availability affects entry of Listeria monocytogenes into the enterocytelike cell line Caco-2 / Conte, Maria Pia; Longhi, Catia; M., Polidoro; G., Petrone; V., Buonfiglio; S., Disanto; E., Papi; Seganti, Lucilla; P., Visca; Valenti, Piera. - In: INFECTION AND IMMUNITY. - ISSN 0019-9567. - ELETTRONICO. - 64:9(1996), pp. 3925-3929.
Iron availability affects entry of Listeria monocytogenes into the enterocytelike cell line Caco-2
CONTE, Maria Pia;LONGHI, Catia;SEGANTI, Lucilla;VALENTI, PIERA
1996
Abstract
The influence of iron on the entry of Listeria monocytogenes into Caco-2 cells was studied. Iron availability was found to modify the surface hydrophobicity and protein profile of L. monocytogenes, with the result that cell invasion strongly increased upon bacterial growth in iron-rich medium. The enhanced invasive capability of iron-overloaded L. monocytogenes cells correlates to the higher-level expression of the inlAB virulence genes, which were positively iron regulated at the transcriptional level.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
