In last decades, several strategies to prevent bacterial colonization of intravascular catheters and related infections have been developed mostly based on the adsorption and/or entrapment of antimicrobial agents in the polymeric matrix of these medical devices. However, the so far available catheters, impregnated with a couple of differently acting antibiotics, showed a relatively short-term antimicrobial activity, usually no more than 7 days, with a massive antibiotic release within the first 24-48 hrs, followed by the discharge of sub-inhibitory doses until complete release of the adsorbed drugs. Further, these medicated catheters are believed to be possibly associated with a risk of emergence of multidrug-resistant pathogens. To overcome these limits, we developed suitably functionalized polyurethanes able to bind rifampin and cefamandole nafate and to entrap polyethylen glycol (PEG) as a pore former agent. Such experimental model is characterized by both a high polymer/antibiotic affinity and the pore-former dependent property to allow the release of high antibiotic amounts for 3-4 weeks. In fact, due to the presence of PEG, entrapped in the polymeric bulk with the antibiotics, the system was able to inhibit the growth of a rifampin resistant strain of Staphylococcus aureus for 23 days. Further, a synergistic effect of the two antibiotic molecules released from the polymers was also observed. These results suggest that a combined entrapment of suitable antibiotic and pore former molecules into functionalized polyurethanes could represent a new promising approach to prevent microbial colonization and to limit the emergence of antibiotic resistant microrganisms.
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|Titolo:||Functionalized polyurethanes releasing rifampin/cefamandole and polyethylen glycol able to prevent bacterial colonization and the emergence of resistant strains.|
|Data di pubblicazione:||2007|
|Appartiene alla tipologia:||04a Atto di comunicazione a congresso|