Primary CD8+ T-cell response to soluble ovalbumin is improved by chloroquine treatment in vivo

Garulli, B.; Stillitano, M. G.; Barnaba, Vincenzo; Castrucci, M. R.

doi:10.1128/cvi.00166-08

The efficiency of cross-presentation of exogenous antigens by dendritic cells (DCs) would seem to be related to the level of antigen escape from massive degradation mediated by lysosomal proteases in an acidic environment. Here, we demonstrate that a short course of treatment with chloroquine in mice during primary immunization with soluble antigens improved the cross-priming of naïve CD8+ T lymphocytes in vivo. More specifically, priming of chloroquine-treated mice with soluble ovalbumin (OVA), OVA associated with alum, or OVA pulsed on DCs was more effective in inducing OVA-specific CD8 + T lymphocytes than was priming of untreated mice. We conclude that chloroquine treatment improves the cross-presentation capacity of DCs and thus the size of effector and memory CD8+ T cells during vaccination. Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Primary CD8+ T-cell response to soluble ovalbumin is improved by chloroquine treatment in vivo / B., Garulli; M. G., Stillitano; Barnaba, Vincenzo; M. R., Castrucci. - In: CLINICAL AND VACCINE IMMUNOLOGY. - ISSN 1556-6811. - 15:10(2008), pp. 1497-1504.

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Titolo:	Primary CD8+ T-cell response to soluble ovalbumin is improved by chloroquine treatment in vivo
Autori:	B. Garulli M. G. Stillitano BARNABA, Vincenzo M. R. Castrucci mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2008
Rivista:	CLINICAL AND VACCINE IMMUNOLOGY
Citazione:	Primary CD8+ T-cell response to soluble ovalbumin is improved by chloroquine treatment in vivo / B., Garulli; M. G., Stillitano; Barnaba, Vincenzo; M. R., Castrucci. - In: CLINICAL AND VACCINE IMMUNOLOGY. - ISSN 1556-6811. - 15:10(2008), pp. 1497-1504.
Handle:	http://hdl.handle.net/11573/24100
Appartiene alla tipologia:	01a Articolo in rivista

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