A versatile atom transfer radical polymerization (ATRP) method for polysaccharide grafting in homogeneous mild conditions without using protecting group chemistry is presented. Water/DMF mixtures with different compositions were used as the solvent. The "grafting-from" approach was used in order to prepare suitable pullulan and dextran ATRP macroinitiators with a well controlled degree of functionalization. Methacrylate and acrylamide monomers were grafted obtaining good control over the number, molecular weight and polydispersity of the grafted chains without homopolymer formation and polysaccharide degradation. The versatility of this method allowed us to prepare comblike derivatives with a wide range of properties (amphiphilic, ionic, and ther-moresponsive) by simply changing the solvent composition and the catalyst. This could make possible the synthesis of new interesting biomaterials starting from a wide range of polysaccharides.
Versatile grafting of polysaccharides in homogeneous mild conditions by using atom transfer radical polymerization / Debora, Bontempo; Masci, Giancarlo; DE LEONARDIS, Piero; Mannina, Luisa; Donatella, Capitani; Crescenzi, Vittorio. - In: BIOMACROMOLECULES. - ISSN 1525-7797. - STAMPA. - 7:7(2006), pp. 2154-2161. [10.1021/bm0601373]
Versatile grafting of polysaccharides in homogeneous mild conditions by using atom transfer radical polymerization
MASCI, Giancarlo
;MANNINA, LUISA;
2006
Abstract
A versatile atom transfer radical polymerization (ATRP) method for polysaccharide grafting in homogeneous mild conditions without using protecting group chemistry is presented. Water/DMF mixtures with different compositions were used as the solvent. The "grafting-from" approach was used in order to prepare suitable pullulan and dextran ATRP macroinitiators with a well controlled degree of functionalization. Methacrylate and acrylamide monomers were grafted obtaining good control over the number, molecular weight and polydispersity of the grafted chains without homopolymer formation and polysaccharide degradation. The versatility of this method allowed us to prepare comblike derivatives with a wide range of properties (amphiphilic, ionic, and ther-moresponsive) by simply changing the solvent composition and the catalyst. This could make possible the synthesis of new interesting biomaterials starting from a wide range of polysaccharides.File | Dimensione | Formato | |
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Bontempo_ Versatile_ 2006.pdf
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