Coronary artery bypass grafting was performed in a 54-year-old man affected by untreated Fabry's disease. Left internal mammary artery (LIMA) and saphenous vein grafts were implanted. Surgical samples of LIMA revealed diffuse glycosphyngolipid infiltration of smooth muscle cells, whereas SV was normal. After surgery, the patient received antithrombotic and enzyme replacement therapy. At 1-year follow-up, LIMA graft occluded, whereas saphenous vein graft remained patent. In Fabry's disease, veins, probably because of a low pressure load, seem to be spared from glycosphingolipid accumulation and are more suitable than arteries for grafting. A preventive histology of conduits is suggested before graft selection. © 2007 Elsevier Inc. All rights reserved.
Coronary artery bypass grafting for Fabry's disease: veins more suitable than arteries? / Chimenti, Cristina; Emanuela, Morgante; Giuseppe, Critelli; Russo, Matteo Antonio; Frustaci, Andrea. - In: HUMAN PATHOLOGY. - ISSN 0046-8177. - STAMPA. - 38:12(2007), pp. 1864-1867. [10.1016/j.humpath.2007.07.001]
Coronary artery bypass grafting for Fabry's disease: veins more suitable than arteries?
CHIMENTI, CRISTINA;RUSSO, Matteo Antonio;FRUSTACI, ANDREA
2007
Abstract
Coronary artery bypass grafting was performed in a 54-year-old man affected by untreated Fabry's disease. Left internal mammary artery (LIMA) and saphenous vein grafts were implanted. Surgical samples of LIMA revealed diffuse glycosphyngolipid infiltration of smooth muscle cells, whereas SV was normal. After surgery, the patient received antithrombotic and enzyme replacement therapy. At 1-year follow-up, LIMA graft occluded, whereas saphenous vein graft remained patent. In Fabry's disease, veins, probably because of a low pressure load, seem to be spared from glycosphingolipid accumulation and are more suitable than arteries for grafting. A preventive histology of conduits is suggested before graft selection. © 2007 Elsevier Inc. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
