The pathogenic mechanism underlying the hyperproliferation of keratinocytes in psoriasis is still not completely clarified. The production of cytokines released by activated T lymphocytes infiltrating the upper dermis probably has a crucial role. Even dermal fibroblasts can participate in the process through the secretion of growth factors, and some studies have reported an increased expression of the insulin-like growth factor 1. Few studies, however, have focused on the possible involvement of the keratinocyte growth factor (KGF/FGF-7) and the fibroblast growth factor 10 (FGF-10/KGF-2), which are secreted by fibroblasts and stimulate keratinocyte proliferation acting through a receptor specifically expressed by epithelial cells. The aim of this study was to investigate the expression of KGF and FGF-10 on the skin of patients with psoriasis by immunohistochemical analysis and to evaluate the correlation with the lymphocyte infiltrate and the epidermal proliferation. Immunostaining for KGF and FGF-10 showed that both the growth factors are upregulated in the upper dermis of psoriatic skin, and that the expression is correlated with the presence of T-cell infiltrate and with keratinocyte proliferation. Our data suggest that in psoriatic lesions activated lymphocytes can stimulate fibroblasts to produce KGF and FGF-10, which in turn contribute to sustain the hyperproliferative status of the keratinocytes.

Immunohistochemical analysis of keratinocyte growth factor and fibroblast growth factor 10 expression in psoriasis / D., Kovacs; M., Falchi; G., Cardinali; Raffa, Salvatore; M., Carducci; C., Cota; A., Amantea; Torrisi, Maria Rosaria; M., Picardo. - In: EXPERIMENTAL DERMATOLOGY. - ISSN 0906-6705. - 14:2(2005), pp. 130-137. [10.1111/j.0906-6705.2005.00261.x]

Immunohistochemical analysis of keratinocyte growth factor and fibroblast growth factor 10 expression in psoriasis

RAFFA, SALVATORE;TORRISI, Maria Rosaria;
2005

Abstract

The pathogenic mechanism underlying the hyperproliferation of keratinocytes in psoriasis is still not completely clarified. The production of cytokines released by activated T lymphocytes infiltrating the upper dermis probably has a crucial role. Even dermal fibroblasts can participate in the process through the secretion of growth factors, and some studies have reported an increased expression of the insulin-like growth factor 1. Few studies, however, have focused on the possible involvement of the keratinocyte growth factor (KGF/FGF-7) and the fibroblast growth factor 10 (FGF-10/KGF-2), which are secreted by fibroblasts and stimulate keratinocyte proliferation acting through a receptor specifically expressed by epithelial cells. The aim of this study was to investigate the expression of KGF and FGF-10 on the skin of patients with psoriasis by immunohistochemical analysis and to evaluate the correlation with the lymphocyte infiltrate and the epidermal proliferation. Immunostaining for KGF and FGF-10 showed that both the growth factors are upregulated in the upper dermis of psoriatic skin, and that the expression is correlated with the presence of T-cell infiltrate and with keratinocyte proliferation. Our data suggest that in psoriatic lesions activated lymphocytes can stimulate fibroblasts to produce KGF and FGF-10, which in turn contribute to sustain the hyperproliferative status of the keratinocytes.
2005
fibroblast growth factor 10; growth factors; keratinocyte growth factor; lymphocyte infiltrate; psoriasis
01 Pubblicazione su rivista::01a Articolo in rivista
Immunohistochemical analysis of keratinocyte growth factor and fibroblast growth factor 10 expression in psoriasis / D., Kovacs; M., Falchi; G., Cardinali; Raffa, Salvatore; M., Carducci; C., Cota; A., Amantea; Torrisi, Maria Rosaria; M., Picardo. - In: EXPERIMENTAL DERMATOLOGY. - ISSN 0906-6705. - 14:2(2005), pp. 130-137. [10.1111/j.0906-6705.2005.00261.x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/239774
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