A simple electrochemical synthesis of -lactams has been developed using constant current electrolysis in a suitable solvent-supporting electrolyte solutions, with subsequent addition of bromoamides. The regio- and stereo-selectivity of the electrochemically-induced cyclization of bromoamides to -lactams, via N C4 bond formation, has been evidenced. This synthesis avoids any addition of bases and probases and gives -lactams in high yields.
An electrochemical alternative strategy to the synthesis of β-lactams via N-C4 bond formation / Feroci, Marta; Orsini, M.; Palombi, L.; Rossi, L.; Inesi, Achille. - In: ELECTROCHIMICA ACTA. - ISSN 0013-4686. - STAMPA. - 50:(2005), pp. 2029-2036. [10.1016/j.electacta.2004.09.011]
An electrochemical alternative strategy to the synthesis of β-lactams via N-C4 bond formation
FEROCI, Marta;INESI, ACHILLE
2005
Abstract
A simple electrochemical synthesis of -lactams has been developed using constant current electrolysis in a suitable solvent-supporting electrolyte solutions, with subsequent addition of bromoamides. The regio- and stereo-selectivity of the electrochemically-induced cyclization of bromoamides to -lactams, via N C4 bond formation, has been evidenced. This synthesis avoids any addition of bases and probases and gives -lactams in high yields.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.