A standardized red orange extract (Red Orange Complex, ROC) has been evaluated for its potential protective effect on ethanol- and indomethacin-induced gastric lesions in rats. Oral administration of the ROC significantly prevented the development of gastric lesions in these experimental models. In addition, the effect of the ROC oil the spontaneous healing of acetylsalicylic acid (ASA) ulcers in rats was examined. The spontaneous healing of gastric ulcer was significantly accelerated by repeated administration of the ROC. The histological condition of the mucosa, examined by scanning electronic microscopy (SEM), confirmed the in vivo data. The results, on the whole, indicate that the ROC possesses javourable antiulcer and cytoprotective properties in rat.
Antiulcer potential of a standardized extract of red orange juice in the rat / Federica, Vitali; Antonella, Saija; F., Bonina; S., Franchitto; Artico, Marco; Tita, Beatrice. - In: INTERNATIONAL JOURNAL OF FOOD PROPERTIES. - ISSN 1094-2912. - 10:2(2007), pp. 331-344. [10.1080/10942910601113319]
Antiulcer potential of a standardized extract of red orange juice in the rat
ARTICO, Marco;TITA, Beatrice
2007
Abstract
A standardized red orange extract (Red Orange Complex, ROC) has been evaluated for its potential protective effect on ethanol- and indomethacin-induced gastric lesions in rats. Oral administration of the ROC significantly prevented the development of gastric lesions in these experimental models. In addition, the effect of the ROC oil the spontaneous healing of acetylsalicylic acid (ASA) ulcers in rats was examined. The spontaneous healing of gastric ulcer was significantly accelerated by repeated administration of the ROC. The histological condition of the mucosa, examined by scanning electronic microscopy (SEM), confirmed the in vivo data. The results, on the whole, indicate that the ROC possesses javourable antiulcer and cytoprotective properties in rat.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.