Although respiratory syncytial (RS) virus is the major cause of bronchiolitis and pneumonia in young children, the factors that regulate the associated lung inflammation have not been defined. The levels of interleukin (IL)10, IL-12, and interferon (IFN) were determined in the nasal wash samples from 20 infants with a clinical diagnosis of bronchiolitis, seven with confirmed RS virus infections and 9 control children without respiratory illnesses. IL-10 levels were significantly higher in acute nasal wash samples (1-4 d post-hospitalization) from RS virus- infected infants than in convalescent samples from these children (14-21 d post-hospitalization), from children with other forms of bronchiolitis and from control children. In contrast, only one RS virus-infected infant had detectable IL-12 in an acute nasal wash sample. IFN activity was not detected in any samples from RS virus-infected children. RS virus infection stimulates IL-10 expression but not IL-12 and IFN, possibly contributing to an ineffective cell-mediated immune response.

Cytokines in the nasal washes of children with respiratory syncytial virus bronchiolitis / Midulla, Fabio; Tromba, Valeria; L., Lo Russo; F., Mileto; G., Sabatino; M., Sgarrella; J. R., Panuska; L., Manganozzi; D., Korn; Moretti, Corrado. - In: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - ISSN 0394-6320. - 19:1(2006), pp. 231-235.

Cytokines in the nasal washes of children with respiratory syncytial virus bronchiolitis

MIDULLA, Fabio;TROMBA, Valeria;MORETTI, Corrado
2006

Abstract

Although respiratory syncytial (RS) virus is the major cause of bronchiolitis and pneumonia in young children, the factors that regulate the associated lung inflammation have not been defined. The levels of interleukin (IL)10, IL-12, and interferon (IFN) were determined in the nasal wash samples from 20 infants with a clinical diagnosis of bronchiolitis, seven with confirmed RS virus infections and 9 control children without respiratory illnesses. IL-10 levels were significantly higher in acute nasal wash samples (1-4 d post-hospitalization) from RS virus- infected infants than in convalescent samples from these children (14-21 d post-hospitalization), from children with other forms of bronchiolitis and from control children. In contrast, only one RS virus-infected infant had detectable IL-12 in an acute nasal wash sample. IFN activity was not detected in any samples from RS virus-infected children. RS virus infection stimulates IL-10 expression but not IL-12 and IFN, possibly contributing to an ineffective cell-mediated immune response.
2006
bronchiolitis; ifn; il-10; il-12; nasal washes; respiratory syncytial virus
01 Pubblicazione su rivista::01a Articolo in rivista
Cytokines in the nasal washes of children with respiratory syncytial virus bronchiolitis / Midulla, Fabio; Tromba, Valeria; L., Lo Russo; F., Mileto; G., Sabatino; M., Sgarrella; J. R., Panuska; L., Manganozzi; D., Korn; Moretti, Corrado. - In: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - ISSN 0394-6320. - 19:1(2006), pp. 231-235.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/238776
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