Rationale. It has been demonstrated that major differences between mice of the C57BL/6J and DBA/2J inbred strains for amphetamine-induced place conditioning (preference and avoidance, respectively) are evident in standard housing conditions but abolished by temporary restricted feeding. This gene-experience model may be usefully exploited to dissect behavioral phenotypes related to place conditioning induced by addictive drugs. Objectives. This study evaluated a number of behavioral phenotypes related to amphetamine-induced place preference for strain differences (C57BL/6J vs DBA/2J) susceptible to be abolished by temporary food restriction. Methods. Mice of the two inbred strains were tested for: (1) conditioned taste aversion and place preference induced by amphetamine within the same dose-range; (2) preference for a novel compartment 24 h after a single exposure to only one of two compartments; (3) amphetamine-induced behavioral sensitization and conditioned hyperactivity; and (4) locomotor activity during exploration of a novel environment. Results. The two strains showed consistent taste aversion at doses of amphetamine that promoted opposite strain-dependent place conditioning. Both strains spent more time exploring the novel rather than the known compartment of the place conditioning apparatus. Instead, only mice of the C57 strain showed amphetamine-induced behavioral sensitization and conditioned hyperactivity. However, temporary food restriction did not affect strain differences for these phenotypes. Finally, C57 mice were more active than DBA in a novel environment and restricted feeding abolished this strain-dependent difference. <LF>Conclusions. These results relate individual differences for amphetamine-induced place conditioning with locomotor response to amphetamine and novelty.

Susceptibility to amphetamine-induced place preference is predicted by locomotor response to novelty and amphetamine in the mouse / Orsini, Cristina; Francesca, Buchini; Pier Vincenzo, Piazza; PUGLISI ALLEGRA, Stefano; Cabib, Simona. - In: PSYCHOPHARMACOLOGY. - ISSN 0033-3158. - STAMPA. - 172:3(2004), pp. 264-270. [10.1007/s00213-003-1647-z]

Susceptibility to amphetamine-induced place preference is predicted by locomotor response to novelty and amphetamine in the mouse

ORSINI, CRISTINA;PUGLISI ALLEGRA, Stefano;CABIB, Simona
2004

Abstract

Rationale. It has been demonstrated that major differences between mice of the C57BL/6J and DBA/2J inbred strains for amphetamine-induced place conditioning (preference and avoidance, respectively) are evident in standard housing conditions but abolished by temporary restricted feeding. This gene-experience model may be usefully exploited to dissect behavioral phenotypes related to place conditioning induced by addictive drugs. Objectives. This study evaluated a number of behavioral phenotypes related to amphetamine-induced place preference for strain differences (C57BL/6J vs DBA/2J) susceptible to be abolished by temporary food restriction. Methods. Mice of the two inbred strains were tested for: (1) conditioned taste aversion and place preference induced by amphetamine within the same dose-range; (2) preference for a novel compartment 24 h after a single exposure to only one of two compartments; (3) amphetamine-induced behavioral sensitization and conditioned hyperactivity; and (4) locomotor activity during exploration of a novel environment. Results. The two strains showed consistent taste aversion at doses of amphetamine that promoted opposite strain-dependent place conditioning. Both strains spent more time exploring the novel rather than the known compartment of the place conditioning apparatus. Instead, only mice of the C57 strain showed amphetamine-induced behavioral sensitization and conditioned hyperactivity. However, temporary food restriction did not affect strain differences for these phenotypes. Finally, C57 mice were more active than DBA in a novel environment and restricted feeding abolished this strain-dependent difference. Conclusions. These results relate individual differences for amphetamine-induced place conditioning with locomotor response to amphetamine and novelty.
2004
addictive drugs; conditioning; context discrimination; exploratory behavior; inbred strain; individual predisposition to disease; life experience; mice
01 Pubblicazione su rivista::01a Articolo in rivista
Susceptibility to amphetamine-induced place preference is predicted by locomotor response to novelty and amphetamine in the mouse / Orsini, Cristina; Francesca, Buchini; Pier Vincenzo, Piazza; PUGLISI ALLEGRA, Stefano; Cabib, Simona. - In: PSYCHOPHARMACOLOGY. - ISSN 0033-3158. - STAMPA. - 172:3(2004), pp. 264-270. [10.1007/s00213-003-1647-z]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/238732
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