Objective: To find out whether parkinsonian patients with levodopa-induced peak-dose dyskinesias are bradykinetic. Methods: The performance of a sequential internally determined arm movement and a simple externally triggered arm movement was studied in a group of dyskinetic parkinsonian patients during their best clinical condition and when they were OFF treatment. Patients' performance was compared with that of an age-matched control group. Movements in the three-dimensional space were recorded by the ELITE motion analysis system. Kinematic variables analysed for the sequential motor task were total movement duration and total pause duration; for the simple motor task, movement duration and reaction time; and for both tasks, movement inaccuracy. Results: When patients were OFF therapy they performed sequential and simple movement tasks slower than healthy subjects whereas when they were dyskinetic they did not. During the sequential task, when the patients were dyskinetic total pause duration shortened and movement inaccuracy increased. Conclusions: Our kinematic finding indicates that parkinsonian patients' with peak-dose dyskinesias are not bradykinetic. Significance: Parkinsonian patients with peak-dose dyskinesias are not bradykinetic, probably because dopamine at peak doses functionally normalizes the mechanisms controlling movement speed. (c) 2005 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Neither simple nor sequential arm movements are bradykinetic in parkinsonian patients with peak-dose dyskinesias / R., Agostino; S., Bagnato; L., Dinapoli; N., Modugno; Berardelli, Alfredo. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1388-2457. - 116:9(2005), pp. 2077-2082. [10.1016/j.clinph.2005.04.027]

Neither simple nor sequential arm movements are bradykinetic in parkinsonian patients with peak-dose dyskinesias

BERARDELLI, Alfredo
2005

Abstract

Objective: To find out whether parkinsonian patients with levodopa-induced peak-dose dyskinesias are bradykinetic. Methods: The performance of a sequential internally determined arm movement and a simple externally triggered arm movement was studied in a group of dyskinetic parkinsonian patients during their best clinical condition and when they were OFF treatment. Patients' performance was compared with that of an age-matched control group. Movements in the three-dimensional space were recorded by the ELITE motion analysis system. Kinematic variables analysed for the sequential motor task were total movement duration and total pause duration; for the simple motor task, movement duration and reaction time; and for both tasks, movement inaccuracy. Results: When patients were OFF therapy they performed sequential and simple movement tasks slower than healthy subjects whereas when they were dyskinetic they did not. During the sequential task, when the patients were dyskinetic total pause duration shortened and movement inaccuracy increased. Conclusions: Our kinematic finding indicates that parkinsonian patients' with peak-dose dyskinesias are not bradykinetic. Significance: Parkinsonian patients with peak-dose dyskinesias are not bradykinetic, probably because dopamine at peak doses functionally normalizes the mechanisms controlling movement speed. (c) 2005 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
2005
bradykinesia; dyskinesias; motor system; parkinson's disease; voluntary movement
01 Pubblicazione su rivista::01a Articolo in rivista
Neither simple nor sequential arm movements are bradykinetic in parkinsonian patients with peak-dose dyskinesias / R., Agostino; S., Bagnato; L., Dinapoli; N., Modugno; Berardelli, Alfredo. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1388-2457. - 116:9(2005), pp. 2077-2082. [10.1016/j.clinph.2005.04.027]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/238724
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