The aim of this study was to compare the positive inotropic effects of 3 different agents with 3 different mechanisms of actions - levosimendan, rolipram, and dobutamine - on human atrial trabecular muscles. Samples of right atrial appendage (1 cm2, 500-1000 mg) were removed and immersed in preoxygenated and modified Tyrode solution. In oxygenated Tyrode solution, preparations were used to investigate the concentration-effect relationship of levosimendan, dobutamine, and rolipram on percentage developed tension (DT), from 10-9 to 10-4 M, each concentration for 15 minutes. All 3 agents produced concentration-dependent increments in DT. We found that levosimendan was the most efficacious positive inotropic agent on isolated human atrial trabeculae. Both the sensitivity (pD2) and maximum response (E max) of human atrial trabeculae to levosimendan (6.711 ± 0.26 and 23.2 ± 2.2 mN, respectively) were significantly greater than those of dobutamine (6.663 ± 0.19 and 17.6 ± 2.8 mN)and rolipram (6.497 ± 0.18 and 15.0 ± 1.0 mN). pD2 and Emax values for dobutamine were significantly higher than those for rolipram. It was suggested that because of its potential to enhance cardiac performance without predisposition to calcium-induced arrhythmias, levosimendan might be more useful as a positive inotropic agent in clinical practice.

Comparision of the inotropic effects of levosimendan, rolipram, and dobutamine on human atrial trabeculae / Coskun, Usta; Puddu, Paolo Emilio; Papalia, Ugo; Vincenzo De, Santis; Domenico, Vitale; Tritapepe, Luigi; Mazzesi, Giuseppe; Miraldi, Fabio; Sadi S., Ozdem. - In: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. - ISSN 0160-2446. - 44:5(2004), pp. 622-625. [10.1097/00005344-200411000-00017]

Comparision of the inotropic effects of levosimendan, rolipram, and dobutamine on human atrial trabeculae

PUDDU, Paolo Emilio;PAPALIA, Ugo;TRITAPEPE, Luigi;MAZZESI, Giuseppe;MIRALDI, Fabio;
2004

Abstract

The aim of this study was to compare the positive inotropic effects of 3 different agents with 3 different mechanisms of actions - levosimendan, rolipram, and dobutamine - on human atrial trabecular muscles. Samples of right atrial appendage (1 cm2, 500-1000 mg) were removed and immersed in preoxygenated and modified Tyrode solution. In oxygenated Tyrode solution, preparations were used to investigate the concentration-effect relationship of levosimendan, dobutamine, and rolipram on percentage developed tension (DT), from 10-9 to 10-4 M, each concentration for 15 minutes. All 3 agents produced concentration-dependent increments in DT. We found that levosimendan was the most efficacious positive inotropic agent on isolated human atrial trabeculae. Both the sensitivity (pD2) and maximum response (E max) of human atrial trabeculae to levosimendan (6.711 ± 0.26 and 23.2 ± 2.2 mN, respectively) were significantly greater than those of dobutamine (6.663 ± 0.19 and 17.6 ± 2.8 mN)and rolipram (6.497 ± 0.18 and 15.0 ± 1.0 mN). pD2 and Emax values for dobutamine were significantly higher than those for rolipram. It was suggested that because of its potential to enhance cardiac performance without predisposition to calcium-induced arrhythmias, levosimendan might be more useful as a positive inotropic agent in clinical practice.
2004
atrial muscle; dobutamine; levosimendan; rolipram
01 Pubblicazione su rivista::01a Articolo in rivista
Comparision of the inotropic effects of levosimendan, rolipram, and dobutamine on human atrial trabeculae / Coskun, Usta; Puddu, Paolo Emilio; Papalia, Ugo; Vincenzo De, Santis; Domenico, Vitale; Tritapepe, Luigi; Mazzesi, Giuseppe; Miraldi, Fabio; Sadi S., Ozdem. - In: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. - ISSN 0160-2446. - 44:5(2004), pp. 622-625. [10.1097/00005344-200411000-00017]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/238610
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 21
  • ???jsp.display-item.citation.isi??? 22
social impact