Twenty-six chemical elements and oxidative status were determined in serum of 12 patients with first demyelinating episode and brain magnetic resonance imaging compatible with the disease at different time points. Quantifications of Al, Ba, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Hg, Li, Mg, Mn, Mo, Ni, Pb, Sb, Si, Sn, Sr, V, Tl, W, Zn and Zr, as well as of serum oxidative status and antioxidant capacity were carried out. The results were compared with values obtained from healthy subjects living in the same geographic area. Concentration variability, expressed as coefficient of variation (CV), was evaluated over a six months longitudinal follow-up. The CV was higher for Li and Pb, while showed minimal variation for Ca, Cu, Mg and Zn - elements strictly body regulated. Significant difference (p ≤ 0.05) in mean concentrations of Ba, Ca, Cd, Cr, Li, Mn, Mo, Ni, Sb, Si, Sn and Zr between patients at time 0 and controls was also found.

Concentration of elements in serum of patients affected by multiple sclerosis with first demyelinating episode: A six-month longitudinal follow-up study / Visconti, Andrea; Cotichini, Rodolfo; Stefania, Cannoni; Boccatonda, Bruno; G., Forte; A., Ghazaryan; S., Santucci; C., D'Ippolito; M. A., Stazi; Salvetti, Marco; A., Alimonti; Ristori, Giovanni. - In: ANNALI DELL'ISTITUTO SUPERIORE DI SANITÀ. - ISSN 0021-2571. - 41:2(2005), pp. 217-222.

Concentration of elements in serum of patients affected by multiple sclerosis with first demyelinating episode: A six-month longitudinal follow-up study

VISCONTI, ANDREA;COTICHINI, Rodolfo;BOCCATONDA, Bruno;SALVETTI, Marco;RISTORI, GIOVANNI
2005

Abstract

Twenty-six chemical elements and oxidative status were determined in serum of 12 patients with first demyelinating episode and brain magnetic resonance imaging compatible with the disease at different time points. Quantifications of Al, Ba, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Hg, Li, Mg, Mn, Mo, Ni, Pb, Sb, Si, Sn, Sr, V, Tl, W, Zn and Zr, as well as of serum oxidative status and antioxidant capacity were carried out. The results were compared with values obtained from healthy subjects living in the same geographic area. Concentration variability, expressed as coefficient of variation (CV), was evaluated over a six months longitudinal follow-up. The CV was higher for Li and Pb, while showed minimal variation for Ca, Cu, Mg and Zn - elements strictly body regulated. Significant difference (p ≤ 0.05) in mean concentrations of Ba, Ca, Cd, Cr, Li, Mn, Mo, Ni, Sb, Si, Sn and Zr between patients at time 0 and controls was also found.
2005
chemical elements; first demyelinating episode; multiple sclerosis; oxidative stress; serum
01 Pubblicazione su rivista::01a Articolo in rivista
Concentration of elements in serum of patients affected by multiple sclerosis with first demyelinating episode: A six-month longitudinal follow-up study / Visconti, Andrea; Cotichini, Rodolfo; Stefania, Cannoni; Boccatonda, Bruno; G., Forte; A., Ghazaryan; S., Santucci; C., D'Ippolito; M. A., Stazi; Salvetti, Marco; A., Alimonti; Ristori, Giovanni. - In: ANNALI DELL'ISTITUTO SUPERIORE DI SANITÀ. - ISSN 0021-2571. - 41:2(2005), pp. 217-222.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/237887
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