Overexpression of intracellular Notch plays an important role in the generation of human acute lymphoblastic T cell leukemia (T-ALL). In mouse models, it was shown that Notch-dependent T-ALL required pre-TCR signaling. Here we show that pre-TCR signaling is required to condition mice for Notch-dependent transformation but that it is not required to sustain malignant growth of T-ALL. In contrast to previous studies, we found that disease development does not require pre-TCR but that it can be accelerated in Rag2(-/-) mice by transient mimicking of pre-TCR signals.
Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling / Campese, Antonio Francesco; A. I., Garbe; F. R., Zhang; F., Grassi; Screpanti, Isabella; H., Von Boehmer. - In: BLOOD. - ISSN 0006-4971. - STAMPA. - 108:1(2006), pp. 305-310. [10.1182/blood-2006-01-0143]
Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling
CAMPESE, Antonio Francesco;SCREPANTI, Isabella;
2006
Abstract
Overexpression of intracellular Notch plays an important role in the generation of human acute lymphoblastic T cell leukemia (T-ALL). In mouse models, it was shown that Notch-dependent T-ALL required pre-TCR signaling. Here we show that pre-TCR signaling is required to condition mice for Notch-dependent transformation but that it is not required to sustain malignant growth of T-ALL. In contrast to previous studies, we found that disease development does not require pre-TCR but that it can be accelerated in Rag2(-/-) mice by transient mimicking of pre-TCR signals.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
