Hydroxy-2,3-trans-nonenal (HNE), a major lipid peroxidation product, has been shown to react with specific amino acid residues of proteins and alter their function. In vitro exposure of erythrocyte ghosts and neutrophil membranes to HNE results in the inhibition of ion transport ATPases. Neutrophil membrane Ca2+-ATPase is strongly inhibited by micromolar concentrations of HNE, while HNE is considerably less effective against neutrophil Mg2+-ATPase and the erythrocyte ghost enzymes.

Inhibition of ion transport ATPases by HNE / Crifo', Carlo; Capuozzo, Elisabetta; W., Siems; Salerno, Costantino. - In: BIOFACTORS. - ISSN 0951-6433. - STAMPA. - 24:1-4(2005), pp. 137-140. (Intervento presentato al convegno Berlin Meeting on NNE and Further Lipid Peroxidation Products - From Basic Science to Medicine tenutosi a Berlin, GERMANY nel JUL 06-09, 2004) [10.1002/biof.5520240116].

Inhibition of ion transport ATPases by HNE

CRIFO', Carlo;CAPUOZZO, Elisabetta;SALERNO, Costantino
2005

Abstract

Hydroxy-2,3-trans-nonenal (HNE), a major lipid peroxidation product, has been shown to react with specific amino acid residues of proteins and alter their function. In vitro exposure of erythrocyte ghosts and neutrophil membranes to HNE results in the inhibition of ion transport ATPases. Neutrophil membrane Ca2+-ATPase is strongly inhibited by micromolar concentrations of HNE, while HNE is considerably less effective against neutrophil Mg2+-ATPase and the erythrocyte ghost enzymes.
2005
4-hydroxy-2-nonenal; 4-hydroxynonenal; calcium pump; erythrocyte; erythrocyte ghosts; lipid peroxidation; neutrophil; neutrophil membrane
01 Pubblicazione su rivista::01a Articolo in rivista
Inhibition of ion transport ATPases by HNE / Crifo', Carlo; Capuozzo, Elisabetta; W., Siems; Salerno, Costantino. - In: BIOFACTORS. - ISSN 0951-6433. - STAMPA. - 24:1-4(2005), pp. 137-140. (Intervento presentato al convegno Berlin Meeting on NNE and Further Lipid Peroxidation Products - From Basic Science to Medicine tenutosi a Berlin, GERMANY nel JUL 06-09, 2004) [10.1002/biof.5520240116].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/236994
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