Human neutrophils are short-lived cells that play important roles in host defense and acute inflammation by releasing hydrolytic and cytotoxic proteins and reactive oxygen derivatives. Apoptosis, a physiological mechanism for cell death, regulates both production and survival of neutrophils, representing a basic biological mechanism for this type of cells. Carotenoids may react with toxic oxygen metabolites released by neutrophils to form a multitude of carotenoid cleavage products that exert, in turn, relevant prooxidative biological effects. Recent data suggest that carotenoid oxidation products may affect neutrophil viability and function by exerting proapoptotic activity and interfering with superoxide production by activated cells. The prooxidant and proapoptotic activities of carotenoid oxidation products could account, at least in some cases, for the procancerogenic properties of carotenoid rich diet.
Effect of carotenoid oxidation products on neutrophil viability and function / Salerno, Costantino; Crifo', Carlo; Capuozzo, Elisabetta; O., Sommerburg; C. D., Langhans; W., Siems. - In: BIOFACTORS. - ISSN 0951-6433. - STAMPA. - 24:1-4(2005), pp. 185-192. (Intervento presentato al convegno Berlin Meeting on NNE and Further Lipid Peroxidation Products - From Basic Science to Medicine tenutosi a Berlin, GERMANY nel JUL 06-09, 2004) [10.1002/biof.5520240122].
Effect of carotenoid oxidation products on neutrophil viability and function
SALERNO, Costantino;CRIFO', Carlo;CAPUOZZO, Elisabetta;
2005
Abstract
Human neutrophils are short-lived cells that play important roles in host defense and acute inflammation by releasing hydrolytic and cytotoxic proteins and reactive oxygen derivatives. Apoptosis, a physiological mechanism for cell death, regulates both production and survival of neutrophils, representing a basic biological mechanism for this type of cells. Carotenoids may react with toxic oxygen metabolites released by neutrophils to form a multitude of carotenoid cleavage products that exert, in turn, relevant prooxidative biological effects. Recent data suggest that carotenoid oxidation products may affect neutrophil viability and function by exerting proapoptotic activity and interfering with superoxide production by activated cells. The prooxidant and proapoptotic activities of carotenoid oxidation products could account, at least in some cases, for the procancerogenic properties of carotenoid rich diet.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
