Because of toxicity at high concentrations, nitric oxide (NO) contributes to spinal cord injury (SCI) secondary lesions. At low concentrations NO modulates nuclear factor–kB (NF-kB) activation. The authors investigated the activity of neuronal and endothelial NO synthase (nNOS and eNOS) to determine correlations with NF- kB activation and inducible NOS (iNOS) expression soon after SCI.
Early nuclear factor-kappaB activation and inducible nitric oxide synthase expression in injured spinal cord neurons correlating with a diffuse reduction of constitutive nitric oxide synthase activity / Miscusi, Massimo; Ebner, F; Ceccariglia, S; Menegazzi, M; Mariotto, S; Berra, L; DEL FA, A; Gangitano, C; Lauretti, L; Missori, Paolo; Delfini, Roberto; Suzuki, H.. - In: JOURNAL OF NEUROSURGERY. SPINE. - ISSN 1547-5654. - STAMPA. - 4:6(2006), pp. 485-493. [10.3171/spi.2006.4.6.485]
Early nuclear factor-kappaB activation and inducible nitric oxide synthase expression in injured spinal cord neurons correlating with a diffuse reduction of constitutive nitric oxide synthase activity.
MISCUSI, MASSIMO;MISSORI, Paolo;DELFINI, Roberto;
2006
Abstract
Because of toxicity at high concentrations, nitric oxide (NO) contributes to spinal cord injury (SCI) secondary lesions. At low concentrations NO modulates nuclear factor–kB (NF-kB) activation. The authors investigated the activity of neuronal and endothelial NO synthase (nNOS and eNOS) to determine correlations with NF- kB activation and inducible NOS (iNOS) expression soon after SCI.| File | Dimensione | Formato | |
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