The aim of this multicenter GIMEMA study was to correlate autoimmune complications (AIC) in B-cell chronic lymphocytic leukemia (B-CLL) with stage and therapy. Autoimmune hemolytic anemia (129/194 cases) and autoimmune thrombocytopenia (35/194 cases) were typically present in advanced and multi-treated disease. Age over the median, stage C and first and second line therapy were identified as independent risk factors by multivariate analysis. In contrast, non-hematologic AIC (30/194 cases) and the presence of serological markers of autoimmunity were mostly observed in early B-CLL, suggesting different pathogenic mechanisms underlying hematologic and non-hematologic autoimmune phenomena in B-CLL.
Relationship between autoimmune phenomena and disease stage and therapy in B-cell chronic lymphocytic leukemia / W., B., S., C., R. M., A., Mauro, F.R., A., A., R., C., A., C., L., L., E. M., P., P., P., V., L., Girelli, G., Mandelli, F., A., Z., Gimema Chronic Lymphocytic Leukemia, G.. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 91:12(2006), pp. 1689-1692.
Relationship between autoimmune phenomena and disease stage and therapy in B-cell chronic lymphocytic leukemia
MAURO, Francesca Romana;GIRELLI, Gabriella;MANDELLI, Franco;
2006
Abstract
The aim of this multicenter GIMEMA study was to correlate autoimmune complications (AIC) in B-cell chronic lymphocytic leukemia (B-CLL) with stage and therapy. Autoimmune hemolytic anemia (129/194 cases) and autoimmune thrombocytopenia (35/194 cases) were typically present in advanced and multi-treated disease. Age over the median, stage C and first and second line therapy were identified as independent risk factors by multivariate analysis. In contrast, non-hematologic AIC (30/194 cases) and the presence of serological markers of autoimmunity were mostly observed in early B-CLL, suggesting different pathogenic mechanisms underlying hematologic and non-hematologic autoimmune phenomena in B-CLL.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
