Diltiazem (DTZ) is an optically active calcium channel blocker having a benzodiazepine structure. The drug used in therapy is (+)-cis-diltiazem with configuration (2S, 3S). To describe the analytical profile of DTZ different stationary phases (RP-18, RP-8, monolithic support) were tested. The best separation of DTZ from A, 13, E and F was obtained using as stationary phase a RP-8 or a monolithic RP-18. The characterization of impurities was carried out using two analytical systems, HPLC and HPLC/MS. (c) 2004 Elsevier B.V. All rights reserved.
Analysis of diltiazem and its related substances by HPLC and HPLC/MS / Quaglia, Maria Giovanna; E., Donati; S., Fanali; E., Bossu; A., Montinaro; Buiarelli, Francesca. - In: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. - ISSN 0731-7085. - ELETTRONICO. - 37:4(2005), pp. 695-701. [10.1016/j.jpba.2004.11.050]
Analysis of diltiazem and its related substances by HPLC and HPLC/MS
QUAGLIA, Maria Giovanna;BUIARELLI, Francesca
2005
Abstract
Diltiazem (DTZ) is an optically active calcium channel blocker having a benzodiazepine structure. The drug used in therapy is (+)-cis-diltiazem with configuration (2S, 3S). To describe the analytical profile of DTZ different stationary phases (RP-18, RP-8, monolithic support) were tested. The best separation of DTZ from A, 13, E and F was obtained using as stationary phase a RP-8 or a monolithic RP-18. The characterization of impurities was carried out using two analytical systems, HPLC and HPLC/MS. (c) 2004 Elsevier B.V. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
