Objective: The present study was conducted to evaluate whether receptor-mediated endocytosis of epidermal growth factor occurs in human chorion laeve at term gestation. Methods: Electron microscopy examination of labeled epidermal growth factor-receptor complexes. Results: Epidermal growth factor-receptor complexes were found to aggregate on cell surface and subsequently become internalized into endocytic vescicles just beneath the cell surface. Conclusion: Receptor-mediated endocytosis of epidermal growth factor is operative in the human chorion at term and, consistent with the hypotesis that epidermal growth factor-receptor in the above tissues are functionally active.
Visualization of aggregation and internalization of the epidermal growth factor-receptor complex in the human chorion laeve at term gestation / C., Ticconi; Petrozza, Vincenzo; Carpino, Francesco; G., Loyola; E., Piccione. - In: ITALIAN JOURNAL OF GYNAECOLOGY & OBSTETRICS. - ISSN 1121-8339. - 8:4(1996), pp. 140-143.
Visualization of aggregation and internalization of the epidermal growth factor-receptor complex in the human chorion laeve at term gestation
PETROZZA, Vincenzo;CARPINO, Francesco;
1996
Abstract
Objective: The present study was conducted to evaluate whether receptor-mediated endocytosis of epidermal growth factor occurs in human chorion laeve at term gestation. Methods: Electron microscopy examination of labeled epidermal growth factor-receptor complexes. Results: Epidermal growth factor-receptor complexes were found to aggregate on cell surface and subsequently become internalized into endocytic vescicles just beneath the cell surface. Conclusion: Receptor-mediated endocytosis of epidermal growth factor is operative in the human chorion at term and, consistent with the hypotesis that epidermal growth factor-receptor in the above tissues are functionally active.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.