Objective: The present study was conducted to evaluate whether receptor-mediated endocytosis of epidermal growth factor occurs in human chorion laeve at term gestation. Methods: Electron microscopy examination of labeled epidermal growth factor-receptor complexes. Results: Epidermal growth factor-receptor complexes were found to aggregate on cell surface and subsequently become internalized into endocytic vescicles just beneath the cell surface. Conclusion: Receptor-mediated endocytosis of epidermal growth factor is operative in the human chorion at term and, consistent with the hypotesis that epidermal growth factor-receptor in the above tissues are functionally active.
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|Titolo:||Visualization of aggregation and internalization of the epidermal growth factor-receptor complex in the human chorion laeve at term gestation|
|Data di pubblicazione:||1996|
|Appartiene alla tipologia:||01a Articolo in rivista|