We present the results of anelastic spectroscopy on the dynamic properties of lipid complexes widely used as DNA vectors in gene therapy. In particular we studied the cationic/neutral lipid mixtures DOTAP/DOPE, DOTAP/DMPC and the single lipids, DOTAP (di-oleoyl trimethylammonium propane), DOPE (di-oleoyl phosphatidylethanolamine), DMPC (dimyristoyl phosphatidylcholine) and DDAB (dimethyldioctadecylammonium), deposited on a solid silicon(1 0 0) substrate. Two relaxation processes have been observed at about 200 and 140 K in mixtures of cationic and neutral lipids, which are due to a dynamics in the membrane plane on time scales accessible to anelastic spectroscopy. The presence of the two processes appears to be a general phenomenon independent of the lipid type, and is connected to the motion of lipids and lipid domains in the membrane plane.

Anelastic spectroscopy as a probe of dynamic properties in lipid membranes / C., Castellano; J., Generosi; Pozzi, Daniela; Cantelli, Rosario. - In: MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING. - ISSN 0921-5093. - 442:1-2 SPEC. ISS.(2006), pp. 375-378. ((Intervento presentato al convegno 14th International Conference on Internal Friction and Mechanical Spectroscopy (ICIFMS-14) tenutosi a Kyoto, JAPAN nel SEP 05-09, 2005 [10.1016/j.msea.2006.02.225].

Anelastic spectroscopy as a probe of dynamic properties in lipid membranes

POZZI, DANIELA;CANTELLI, Rosario
2006

Abstract

We present the results of anelastic spectroscopy on the dynamic properties of lipid complexes widely used as DNA vectors in gene therapy. In particular we studied the cationic/neutral lipid mixtures DOTAP/DOPE, DOTAP/DMPC and the single lipids, DOTAP (di-oleoyl trimethylammonium propane), DOPE (di-oleoyl phosphatidylethanolamine), DMPC (dimyristoyl phosphatidylcholine) and DDAB (dimethyldioctadecylammonium), deposited on a solid silicon(1 0 0) substrate. Two relaxation processes have been observed at about 200 and 140 K in mixtures of cationic and neutral lipids, which are due to a dynamics in the membrane plane on time scales accessible to anelastic spectroscopy. The presence of the two processes appears to be a general phenomenon independent of the lipid type, and is connected to the motion of lipids and lipid domains in the membrane plane.
anelastic spectroscopy; dynamics of lipids; lipid membranes
01 Pubblicazione su rivista::01a Articolo in rivista
Anelastic spectroscopy as a probe of dynamic properties in lipid membranes / C., Castellano; J., Generosi; Pozzi, Daniela; Cantelli, Rosario. - In: MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING. - ISSN 0921-5093. - 442:1-2 SPEC. ISS.(2006), pp. 375-378. ((Intervento presentato al convegno 14th International Conference on Internal Friction and Mechanical Spectroscopy (ICIFMS-14) tenutosi a Kyoto, JAPAN nel SEP 05-09, 2005 [10.1016/j.msea.2006.02.225].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/235614
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