Botulinum toxin type A (BoNT-A) acts peripherally by inhibiting acetylcholine release from the presynaptic neuromuscular terminals, thus weakening muscle contraction, and its clinical benefit depends primarily on the toxin's peripheral action. In addition to acting directly at the neuromuscular junction, the toxin alters sensory inputs to the central nervous system, thus indirectly inducing secondary central changes. Some of the long-term clinical benefits of BoNT-A treatment may also reflect plastic changes in motor output after the reorganization of synaptic density.

Neurophysiological effects of botulinum toxin type A / G., Abbruzzese; Berardelli, Alfredo. - In: NEUROTOXICITY RESEARCH. - ISSN 1029-8428. - 9:2-3(2006), pp. 109-114. [10.1007/bf03033927]

Neurophysiological effects of botulinum toxin type A

BERARDELLI, Alfredo
2006

Abstract

Botulinum toxin type A (BoNT-A) acts peripherally by inhibiting acetylcholine release from the presynaptic neuromuscular terminals, thus weakening muscle contraction, and its clinical benefit depends primarily on the toxin's peripheral action. In addition to acting directly at the neuromuscular junction, the toxin alters sensory inputs to the central nervous system, thus indirectly inducing secondary central changes. Some of the long-term clinical benefits of BoNT-A treatment may also reflect plastic changes in motor output after the reorganization of synaptic density.
2006
botulinum toxin; central effects; neurophysiology; presynaptic effects
01 Pubblicazione su rivista::01a Articolo in rivista
Neurophysiological effects of botulinum toxin type A / G., Abbruzzese; Berardelli, Alfredo. - In: NEUROTOXICITY RESEARCH. - ISSN 1029-8428. - 9:2-3(2006), pp. 109-114. [10.1007/bf03033927]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/233769
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