The topological bases of essentiality in the yeast metabolic network from the perspective of double mutations are the subject of this study. A strong relationship between essentiality and the ‘missing alternative’ topological property is shown in terms of the presence of multiple genes synthesizing the same enzyme, supplementary enzymes participating in the same metabolic reaction, and availability of other pathways in the graph connecting the separated nodes after the knockouts. We demonstrate that the ‘missing alternative’ paradigm is sufficient to explain the generation of essentiality for double mutations in which each single deleted element is non-essential.

Essentiality is an emergent property of metabolic network wiring / Maria Concetta, Palumbo; Colosimo, Alfredo; Farina, Lorenzo; Alessandro, Giuliani. - In: FEBS LETTERS. - ISSN 0014-5793. - 581:13(2007), pp. 2485-2489. [10.1016/j.febslet.2007.04.067]

Essentiality is an emergent property of metabolic network wiring

COLOSIMO, Alfredo;FARINA, Lorenzo;
2007

Abstract

The topological bases of essentiality in the yeast metabolic network from the perspective of double mutations are the subject of this study. A strong relationship between essentiality and the ‘missing alternative’ topological property is shown in terms of the presence of multiple genes synthesizing the same enzyme, supplementary enzymes participating in the same metabolic reaction, and availability of other pathways in the graph connecting the separated nodes after the knockouts. We demonstrate that the ‘missing alternative’ paradigm is sufficient to explain the generation of essentiality for double mutations in which each single deleted element is non-essential.
2007
double mutants; phenotype/genotype relations; systems biology; yeast
01 Pubblicazione su rivista::01a Articolo in rivista
Essentiality is an emergent property of metabolic network wiring / Maria Concetta, Palumbo; Colosimo, Alfredo; Farina, Lorenzo; Alessandro, Giuliani. - In: FEBS LETTERS. - ISSN 0014-5793. - 581:13(2007), pp. 2485-2489. [10.1016/j.febslet.2007.04.067]
File allegati a questo prodotto
File Dimensione Formato  
VE_2007_11573-233095.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 208.8 kB
Formato Adobe PDF
208.8 kB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/233095
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 14
  • Scopus 30
  • ???jsp.display-item.citation.isi??? 27
social impact