Acute alcoholic hepatitis (AAH) is a frequent inflammatory liver disease with high short-term mortality rate. In this review, relationships between alcohol abuse and the epidemiology and the outcomes of AAH are discussed, as well as AAH pathogenesis. The role of endotoxins, tumor necrosis factor a, fibroblasts, and immune response to altered hepatocyte proteins is discussed. The need of a careful prognosis, supported by the use of Maddrey score, by the model for end-stage liver disease [Mayo end-stage liver disease (MELD)] score or by the Glasgow alcoholic hepatitis score, is outlined, as the use of the most effective drugs (glucocorticoids and anti-tumor necrosis factor a infliximab) is recommended only in severe AAH cases. The problems of liver transplant in severe AAH, and the need of a 6-month alcohol abstinence before transplant, are discussed, as well as the need of a careful psychologic assessment before the transplant.

Acute alcoholic hepatitis / Ceccanti, Mauro; Attili, Adolfo Francesco; Giuseppe, Balducci; Attilia, Fabio; Stefano, Giacomelli; Rotondo, Claudia; Sasso, Guido; Elias, Xirouchakis; Attilia, Maria Luisa. - In: JOURNAL OF CLINICAL GASTROENTEROLOGY. - ISSN 0192-0790. - STAMPA. - 40:9(2006), pp. 833-841. [10.1097/01.mcg.0000225570.04773.5d]

Acute alcoholic hepatitis

CECCANTI, Mauro;ATTILI, Adolfo Francesco;ATTILIA, FABIO;ROTONDO, CLAUDIA;SASSO, Guido;ATTILIA, Maria Luisa
2006

Abstract

Acute alcoholic hepatitis (AAH) is a frequent inflammatory liver disease with high short-term mortality rate. In this review, relationships between alcohol abuse and the epidemiology and the outcomes of AAH are discussed, as well as AAH pathogenesis. The role of endotoxins, tumor necrosis factor a, fibroblasts, and immune response to altered hepatocyte proteins is discussed. The need of a careful prognosis, supported by the use of Maddrey score, by the model for end-stage liver disease [Mayo end-stage liver disease (MELD)] score or by the Glasgow alcoholic hepatitis score, is outlined, as the use of the most effective drugs (glucocorticoids and anti-tumor necrosis factor a infliximab) is recommended only in severe AAH cases. The problems of liver transplant in severe AAH, and the need of a 6-month alcohol abstinence before transplant, are discussed, as well as the need of a careful psychologic assessment before the transplant.
2006
alcohol liver disease; alcoholic hepatitis; alcoholism; epidemiology; maddrey; meld
01 Pubblicazione su rivista::01a Articolo in rivista
Acute alcoholic hepatitis / Ceccanti, Mauro; Attili, Adolfo Francesco; Giuseppe, Balducci; Attilia, Fabio; Stefano, Giacomelli; Rotondo, Claudia; Sasso, Guido; Elias, Xirouchakis; Attilia, Maria Luisa. - In: JOURNAL OF CLINICAL GASTROENTEROLOGY. - ISSN 0192-0790. - STAMPA. - 40:9(2006), pp. 833-841. [10.1097/01.mcg.0000225570.04773.5d]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/232812
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