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EnglishThis study demonstrates the expression of functional somatostatin receptor (sstr) subtypes in human circular and longitudinal colonic smooth muscle cells (SMC). Native somatostatin (SS) and sstr subtype-specific analogues were used to characterize the sstr subtypes present in both cell types by contraction/relaxation studies. Qualitative and quantitative mRNA analysis and immunohistochemistry of sstr subtypes were also carried out. sstr subtype 2 mRNA was expressed in circular SMC, and various levels of subtypes 1, 2 and 3 mRNA were expressed in longitudinal colonic SMC. Native SS and each subtype-specific analogue exerted a modest, but significant, contraction, although inhibition of carbachol-induced contraction (relaxation) was the main effect on SMC from both layers. CH-288, a sstr subtype 1-specific analogue, and octreotide, a sstr subtype 2-specific analogue, were the most effective relaxant analogues on longitudinal and circular SMC, respectively. sstr subtypes display a distinct expression pattern on human colonic SMC; on circular SMC, subtype 2 is the only sstr, whereas sstr subtypes 1, 2 and 3 are expressed on human SMC isolated from the longitudinal layer. The contractile effects of SS are mediated through sstr subtype 2 and sstr subtype 1 on circular and longitudinal human colonic SMC, respectively.
Somatostatin receptor subtypes mediate contractility on human colonic smooth muscle cells / Corleto, Vito Domenico; Severi, Carola; G., Romano; I., Tattoli; H. C., Weber; M., Stridsberg; G., Rindi; N., Campanini; F., Tomassoni; U., Pagotto; D. H., Coy; R. T., Jensen; DELLE FAVE, Gianfranco. - In: NEUROGASTROENTEROLOGY AND MOTILITY. - ISSN 1350-1925. - 18:3(2006), pp. 217-225. [10.1111/j.1365-2982.2005.00752.x]
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| Titolo: | Somatostatin receptor subtypes mediate contractility on human colonic smooth muscle cells | |
| Autori: | ||
| Data di pubblicazione: | 2006 | |
| Rivista: | ||
| Citazione: | Somatostatin receptor subtypes mediate contractility on human colonic smooth muscle cells / Corleto, Vito Domenico; Severi, Carola; G., Romano; I., Tattoli; H. C., Weber; M., Stridsberg; G., Rindi; N., Campanini; F., Tomassoni; U., Pagotto; D. H., Coy; R. T., Jensen; DELLE FAVE, Gianfranco. - In: NEUROGASTROENTEROLOGY AND MOTILITY. - ISSN 1350-1925. - 18:3(2006), pp. 217-225. [10.1111/j.1365-2982.2005.00752.x] | |
| Handle: | http://hdl.handle.net/11573/232569 | |
| Appartiene alla tipologia: | 01a Articolo in rivista |
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