The mechanisms underlying spontaneous remission of autoimmune diseases are presently unknown, though regulatory T cells are believed to play a major role in this process. We tested the hypothesis that Th2 and/or other T cell regulatory cytokines cause the spontaneous remission of experimental allergic encephalomyelitis (EAE), a model of Th1-mediated autoimmunity. We analyzed the cytokine profile of lymph node and central nervous system-infiltrating cells in individual SJL mice at different stages of proteolipid protein (PLP) 139-151 peptide-induced EAE. We found that IFN-gamma slowly fades away after clinical recovery, whereas IL-4, IL-10 and transforming growth factor-beta remain low or undetectable. Our peptide-results therefore suggest that regulatory T cells producing anti-inflammatory cytokines are not involved in spontaneous remission of EAE and challenge the view that the Th1/Th2 balance has a key role in EAE regulation.

Lack of Th2 cytokine increase during spontaneous remission of experimental allergic encephalomyelitis / Francesca Di, Rosa; Anna, Francesconi; Antoni Di, Virgilio; Luigi, Finocchi; Isabella, Santilio; Barnaba, Vincenzo. - In: EUROPEAN JOURNAL OF IMMUNOLOGY. - ISSN 0014-2980. - 28:12(1998), pp. 3893-3903. [10.1002/(sici)1521-4141(199812)28:12<3893::aid-immu3893>3.3.co;2-r]

Lack of Th2 cytokine increase during spontaneous remission of experimental allergic encephalomyelitis

BARNABA, Vincenzo
1998

Abstract

The mechanisms underlying spontaneous remission of autoimmune diseases are presently unknown, though regulatory T cells are believed to play a major role in this process. We tested the hypothesis that Th2 and/or other T cell regulatory cytokines cause the spontaneous remission of experimental allergic encephalomyelitis (EAE), a model of Th1-mediated autoimmunity. We analyzed the cytokine profile of lymph node and central nervous system-infiltrating cells in individual SJL mice at different stages of proteolipid protein (PLP) 139-151 peptide-induced EAE. We found that IFN-gamma slowly fades away after clinical recovery, whereas IL-4, IL-10 and transforming growth factor-beta remain low or undetectable. Our peptide-results therefore suggest that regulatory T cells producing anti-inflammatory cytokines are not involved in spontaneous remission of EAE and challenge the view that the Th1/Th2 balance has a key role in EAE regulation.
1998
t cell cytokine; experimental allergic encephalomyelitis; autoimmunity
01 Pubblicazione su rivista::01a Articolo in rivista
Lack of Th2 cytokine increase during spontaneous remission of experimental allergic encephalomyelitis / Francesca Di, Rosa; Anna, Francesconi; Antoni Di, Virgilio; Luigi, Finocchi; Isabella, Santilio; Barnaba, Vincenzo. - In: EUROPEAN JOURNAL OF IMMUNOLOGY. - ISSN 0014-2980. - 28:12(1998), pp. 3893-3903. [10.1002/(sici)1521-4141(199812)28:12<3893::aid-immu3893>3.3.co;2-r]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/23247
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 30
  • ???jsp.display-item.citation.isi??? 25
social impact