Dedicated high-resolution detectors are required for detection of small cancerous breast tumours by molecular imaging with radionuclides. Absorptive collimation is normally applied in imaging single photon emitters, but it results in a strong reduction in detection efficiency. Systems based on electronic collimation are complex and expensive. For these reasons simulations and measurements have been performed to design optimised dedicated high-resolution mini gamma camera. Critical parameters are contrast and signal-to-noise ratio (SNR). Intrinsic performance (spatial resolution, pixel identification, and response linearity and uniformity) were first optimised. Pixellated scintillator arrays (NaI(TI)) of different pixel size were coupled to arrays of PSPMTs with different anode pad dimensions (6 x 6 mm(2) and 3 x 3 mm(2)). Detectors having a field of view (FOV) of 100 x 100 mm(2) and 150 x 200 mm(2) were designed and built. The electronic system allows read out of all the anode pad signals. The collimation technique was then considered and limits of coded aperture option were studied. Preliminary results are presented. (c) 2006 Elsevier B.V. All rights reserved.
Molecular imaging: High-resolution detectors for early diagnosis and therapy monitoring of breast cancer / F., Garibaldi; Cisbani, ; S., Colilli; F., Cusanno; R., Fratoni; F., Giuliani; M., Gricia; M., Lucentini; R., Fratoni; S., Lo Meo; M. L., Magliozzi; F., Santanvenere; Cinti, Maria Nerina; Pani, Roberto; Pellegrini, Rosanna; G., Simonetti; O., Schillaci; S., Del Vecchio; M., Salvatore; S., Majewski; R. C., Lanza; DE VINCENTIS, Giuseppe; Scopinaro, Francesco. - In: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION A, ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT. - ISSN 0168-9002. - STAMPA. - 569:2 SPEC. ISS.(2006), pp. 286-290. (Intervento presentato al convegno 3rd International Conference on Imaging Technologies in Biomedical Sciences tenutosi a Milos, GREECE nel SEP 25-29, 2005) [10.1016/j.nima.2006.08.098].
Molecular imaging: High-resolution detectors for early diagnosis and therapy monitoring of breast cancer
CINTI, Maria Nerina;PANI, Roberto;PELLEGRINI, Rosanna;DE VINCENTIS, Giuseppe;SCOPINARO, Francesco
2006
Abstract
Dedicated high-resolution detectors are required for detection of small cancerous breast tumours by molecular imaging with radionuclides. Absorptive collimation is normally applied in imaging single photon emitters, but it results in a strong reduction in detection efficiency. Systems based on electronic collimation are complex and expensive. For these reasons simulations and measurements have been performed to design optimised dedicated high-resolution mini gamma camera. Critical parameters are contrast and signal-to-noise ratio (SNR). Intrinsic performance (spatial resolution, pixel identification, and response linearity and uniformity) were first optimised. Pixellated scintillator arrays (NaI(TI)) of different pixel size were coupled to arrays of PSPMTs with different anode pad dimensions (6 x 6 mm(2) and 3 x 3 mm(2)). Detectors having a field of view (FOV) of 100 x 100 mm(2) and 150 x 200 mm(2) were designed and built. The electronic system allows read out of all the anode pad signals. The collimation technique was then considered and limits of coded aperture option were studied. Preliminary results are presented. (c) 2006 Elsevier B.V. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
