Successful treatment with intraarticular infliximab for resistant knee monarthritis in a patient with spondylarthropathy - A role for scintigraphy with Tc-99m-infliximab

Positive experiences with intraarticular inflix- imab have been reported in patients with rheumatoid arthritis, ankylosing spondylitis, and Behc¸et’s disease. We used intraarticular infliximab to treat resistant knee monarthritis in a patient with spondylarthropathy. Clinical and laboratory improvement was associated with improvement in scintigraphic findings. This ap- proach is less expensive than intravenous administra- tion of infliximab. We suggest that selection of candi- dates for this innovative therapy should be guided by anti–tumor necrosis factor scintigraphy.