Thermogravimetry (TG) and differential scanning calorimetry (DSC) were used to assess the compatibility between acetaminophen (Ac) and some excipients (polyvinylpyrrolidone (P), magnesium stearate (M), citric acid (C), aspartame (As), mannitol (Mn), cellulose (Cll) and starch (S)) in several of the more commercially available pharmaceutical formulations and in solid binary mixtures. The present study compared thermodynamic data on acetaminophen melting and vaporization processes of pure acetaminophen with those found for several solid mixtures and in some commercially available acetaminophen-based dosage forms. Appreciable modifications occur only for solid mixtures with high content of excipient. Acetaminophen-based dosage forms and its solid binary mixtures usually show "additivity" of calorimetric peaks number of pure components in their calorimetric curve profiles, thus revealing a good thermoanalytical compatibility between acetaminophen and the excipients examined, except for samples containing appreciable content of mannitol. © 2004 Elsevier B.V. All rights reserved.

Thermal analysis study of the interactions between acetaminophen and excipients in solid dosage forms and in some binary mixtures / Tomassetti, Mauro; Catalani, Alessia; V., Rossi; VECCHIO CIPRIOTI, Stefano. - In: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. - ISSN 0731-7085. - 37:5(2005), pp. 949-955. (Intervento presentato al convegno 15th International Symposium on Pharmaceutical and Biomedical Analysis tenutosi a Florence, ITALY nel MAY 02-06, 2004) [10.1016/j.jpba.2004.10.008].

Thermal analysis study of the interactions between acetaminophen and excipients in solid dosage forms and in some binary mixtures

TOMASSETTI, Mauro;CATALANI, Alessia;VECCHIO CIPRIOTI, Stefano
2005

Abstract

Thermogravimetry (TG) and differential scanning calorimetry (DSC) were used to assess the compatibility between acetaminophen (Ac) and some excipients (polyvinylpyrrolidone (P), magnesium stearate (M), citric acid (C), aspartame (As), mannitol (Mn), cellulose (Cll) and starch (S)) in several of the more commercially available pharmaceutical formulations and in solid binary mixtures. The present study compared thermodynamic data on acetaminophen melting and vaporization processes of pure acetaminophen with those found for several solid mixtures and in some commercially available acetaminophen-based dosage forms. Appreciable modifications occur only for solid mixtures with high content of excipient. Acetaminophen-based dosage forms and its solid binary mixtures usually show "additivity" of calorimetric peaks number of pure components in their calorimetric curve profiles, thus revealing a good thermoanalytical compatibility between acetaminophen and the excipients examined, except for samples containing appreciable content of mannitol. © 2004 Elsevier B.V. All rights reserved.
2005
acetaminophen; compatibility; dosage form; excipients; thermal analysis
01 Pubblicazione su rivista::01a Articolo in rivista
Thermal analysis study of the interactions between acetaminophen and excipients in solid dosage forms and in some binary mixtures / Tomassetti, Mauro; Catalani, Alessia; V., Rossi; VECCHIO CIPRIOTI, Stefano. - In: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. - ISSN 0731-7085. - 37:5(2005), pp. 949-955. (Intervento presentato al convegno 15th International Symposium on Pharmaceutical and Biomedical Analysis tenutosi a Florence, ITALY nel MAY 02-06, 2004) [10.1016/j.jpba.2004.10.008].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/231661
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