Objective. To define joint alterations in the wrists of patients with systemic lupus erythematosus (SLE) by ultrasonography (US). Methods. Fifty-two wrists of 26 SLE patients and 30 wrists of 15 healthy controls were evaluated using US by two different experienced operators, blinded to the clinical data. A 14 MHz linear probe was used. Power Doppler (PD) was applied to evaluate the presence of synovial neoangiogenesis as a parameter of active local synovitis. The findings were correlated to the clinical evaluation, serological systemic disease activity parameters (ESR, C3 levels) and the SLE-disease activity score (SLEDAI). Statistical analysis was per,formed by the EPISTAT program. Results. Signs of synovitis were found in 22 wrists (42.3%). Synovial proliferation was present in 10 joints (19.2%), PD positivity in 5 (9.6%) and joint effusion in 13 (25%). Erosions were present in both wrists (3.8%) of one patient. Signs of tenosynovitis of one or more tendons were shown in 23 cases (44.2%). Ganglia were found in 2 joints (3.8%). Changes of the median nerve, joint dislocations, tendons' ruptures, cysts and nodules were never detected. In 14 wrists (26.9%) no alterations were found. There was no correlation between sonographic findings and clinical, laboratory and indexes signs of disease activity. In the control group the only alteration found was tenosynovitis in 1 joint (p < 0.0001). Conclusion. US proved to be an useful technique to detect wrist joint alterations in SLE. These findings may help the physician to modulate treatment strategies and to perform a low cost monitoring of joint disease activity.

Wrist joint involvement in systemic lupus erythematosus. An ultrasonographic study / Iagnocco, Annamaria; A., Ossandon; Coari, Giulio; Conti, Fabrizio; R., Priori; Alessandri, Cristiano; Valesini, Guido. - In: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. - ISSN 0392-856X. - STAMPA. - 22:5(2004), pp. 621-624.

Wrist joint involvement in systemic lupus erythematosus. An ultrasonographic study

IAGNOCCO, Annamaria;COARI, Giulio;CONTI, FABRIZIO;ALESSANDRI, cristiano;VALESINI, Guido
2004

Abstract

Objective. To define joint alterations in the wrists of patients with systemic lupus erythematosus (SLE) by ultrasonography (US). Methods. Fifty-two wrists of 26 SLE patients and 30 wrists of 15 healthy controls were evaluated using US by two different experienced operators, blinded to the clinical data. A 14 MHz linear probe was used. Power Doppler (PD) was applied to evaluate the presence of synovial neoangiogenesis as a parameter of active local synovitis. The findings were correlated to the clinical evaluation, serological systemic disease activity parameters (ESR, C3 levels) and the SLE-disease activity score (SLEDAI). Statistical analysis was per,formed by the EPISTAT program. Results. Signs of synovitis were found in 22 wrists (42.3%). Synovial proliferation was present in 10 joints (19.2%), PD positivity in 5 (9.6%) and joint effusion in 13 (25%). Erosions were present in both wrists (3.8%) of one patient. Signs of tenosynovitis of one or more tendons were shown in 23 cases (44.2%). Ganglia were found in 2 joints (3.8%). Changes of the median nerve, joint dislocations, tendons' ruptures, cysts and nodules were never detected. In 14 wrists (26.9%) no alterations were found. There was no correlation between sonographic findings and clinical, laboratory and indexes signs of disease activity. In the control group the only alteration found was tenosynovitis in 1 joint (p < 0.0001). Conclusion. US proved to be an useful technique to detect wrist joint alterations in SLE. These findings may help the physician to modulate treatment strategies and to perform a low cost monitoring of joint disease activity.
2004
power doppler; sle; tendons; ultrasonography; wrist
01 Pubblicazione su rivista::01a Articolo in rivista
Wrist joint involvement in systemic lupus erythematosus. An ultrasonographic study / Iagnocco, Annamaria; A., Ossandon; Coari, Giulio; Conti, Fabrizio; R., Priori; Alessandri, Cristiano; Valesini, Guido. - In: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. - ISSN 0392-856X. - STAMPA. - 22:5(2004), pp. 621-624.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/231324
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