The prognostic impact of the presence of a familial trait was analyzed in 1449 patient with chronic lymphocytic leukemia (CLL). A family history of hematologic malignancy (HM) was identified in 181 cases (12.5%) and recorded more frequently among female than male patients (HM: p < 0.05; CLL: p < 0.05). The relative was affected by CLL in 89 cases (6%). Familial and sporadic cases showed non-statistically different proportions of advanced stages (10.8 vs 7.1%) and patients requiring therapy (55 vs 60%) and a similar survival probability at 10 years (67 vs 66%). These data suggest that in CLL the presence of a familial trait does not imply an adverse prognosis.

Clinical features and outcome of familial chronic lymphocytic leukemia / Mauro, Francesca Romana; E., Giammartini; M., Gentile; I., Sperduti; V., Valle; Pizzuti, Antonio; Guarini, Anna; D., Giannarelli; Foa, Roberto. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 91:8(2006), pp. 1117-1120.

Clinical features and outcome of familial chronic lymphocytic leukemia

MAURO, Francesca Romana;PIZZUTI, Antonio;GUARINI, Anna;FOA, Roberto
2006

Abstract

The prognostic impact of the presence of a familial trait was analyzed in 1449 patient with chronic lymphocytic leukemia (CLL). A family history of hematologic malignancy (HM) was identified in 181 cases (12.5%) and recorded more frequently among female than male patients (HM: p < 0.05; CLL: p < 0.05). The relative was affected by CLL in 89 cases (6%). Familial and sporadic cases showed non-statistically different proportions of advanced stages (10.8 vs 7.1%) and patients requiring therapy (55 vs 60%) and a similar survival probability at 10 years (67 vs 66%). These data suggest that in CLL the presence of a familial trait does not imply an adverse prognosis.
2006
chronic lymphocytic leukemia; familial; prognosis
01 Pubblicazione su rivista::01a Articolo in rivista
Clinical features and outcome of familial chronic lymphocytic leukemia / Mauro, Francesca Romana; E., Giammartini; M., Gentile; I., Sperduti; V., Valle; Pizzuti, Antonio; Guarini, Anna; D., Giannarelli; Foa, Roberto. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 91:8(2006), pp. 1117-1120.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/231083
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