A series of substituted pyrazolines were synthesized and evaluated for their anticancer activity and for their ability to inhibit P-glycoprotein-mediated multidrug resistance by direct binding to a purified protein domain containing an ATP-binding site and a modulator interacting region. Compounds 2a and e have been found to bind to P-glycoprotein with greater affinity.

Pyrazole Derivatives as Potential Anticancer agents and their Affinity Binding to P-Glycoprotein / F., Manna; Chimenti, Franco; Fioravanti, Rossella; Bolasco, Adriana; Secci, Daniela; Chimenti, Paola; C., Ferlini; G., Scambia. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 15:(2005), pp. 4632-4635. [10.1016/j.bmcl.2005.05.067]

Pyrazole Derivatives as Potential Anticancer agents and their Affinity Binding to P-Glycoprotein

CHIMENTI, Franco;FIORAVANTI, Rossella;BOLASCO, Adriana;SECCI, DANIELA;CHIMENTI, Paola;
2005

Abstract

A series of substituted pyrazolines were synthesized and evaluated for their anticancer activity and for their ability to inhibit P-glycoprotein-mediated multidrug resistance by direct binding to a purified protein domain containing an ATP-binding site and a modulator interacting region. Compounds 2a and e have been found to bind to P-glycoprotein with greater affinity.
2005
01 Pubblicazione su rivista::01a Articolo in rivista
Pyrazole Derivatives as Potential Anticancer agents and their Affinity Binding to P-Glycoprotein / F., Manna; Chimenti, Franco; Fioravanti, Rossella; Bolasco, Adriana; Secci, Daniela; Chimenti, Paola; C., Ferlini; G., Scambia. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 15:(2005), pp. 4632-4635. [10.1016/j.bmcl.2005.05.067]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/231009
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