Previous studies showed the reduction of dopamine transporter immunoreactivity (DAT-IR) in peripheral blood lymphocytes (PBL) in Parkinson's disease. Here we report the reduction of DAT-IR in PBL in the extrapyramidal variant of multiple system atrophy. These results suggest the reduction of DAT-IR in PBL in a variety of neurodegenerative disorders, provided the presence of damage of the central dopaminergic systems. The reduction of DAT-IR in PBL in these disorders may represent a compensatory phenomenon aimed at reducing intracellular dopamine influx and, consequently, dopamine-mediated aggravation of oxidative stress in these cells. © 2008 Springer-Verlag.
Dopamine transporter immunoreactivity in peripheral blood lymphocytes in multiple system atrophy / Buttarelli, Francesca Romana; Annapia, Circella; Clelia, Pellicano; Dorina, Tiple; Morena, Giovannelli; Carlo, Colosimo; Pontieri, FRANCESCO ERNESTO. - In: JOURNAL OF NEURAL TRANSMISSION. - ISSN 0300-9564. - 116:2(2009), pp. 161-165. [10.1007/s00702-008-0170-0]
Dopamine transporter immunoreactivity in peripheral blood lymphocytes in multiple system atrophy
BUTTARELLI, Francesca Romana;Annapia Circella;PONTIERI, FRANCESCO ERNESTO
2009
Abstract
Previous studies showed the reduction of dopamine transporter immunoreactivity (DAT-IR) in peripheral blood lymphocytes (PBL) in Parkinson's disease. Here we report the reduction of DAT-IR in PBL in the extrapyramidal variant of multiple system atrophy. These results suggest the reduction of DAT-IR in PBL in a variety of neurodegenerative disorders, provided the presence of damage of the central dopaminergic systems. The reduction of DAT-IR in PBL in these disorders may represent a compensatory phenomenon aimed at reducing intracellular dopamine influx and, consequently, dopamine-mediated aggravation of oxidative stress in these cells. © 2008 Springer-Verlag.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
