Muscarinic receptors are expressed in several primary and metastatic tumours. In some of these, acetylcholine synthesized by the tumour cells through autocrine mechanism often mediated by muscarinic receptors, can contribute to tumour progression, modulating cell proliferation, survival, migration and angiogenesis. Acetylcholine also appears to be involved in brain tumours. In fact, patients with these pathologies show altered levels of ACh in their cerebrospinal fluid. Astrocytomas, glioblastomas and neuroblastomas express both nicotinic and muscarinic receptors, and their activation enhances different signal transduction pathways involving AKT, PIK3, MAPK and ERK. The present review is focused on recent studies demonstrating the muscarinic receptor involvement in the modulation of proliferation, survival and migration in tumours of the central and peripheral nervous system. These data together with observations reported for other pathologies, open up new interesting therapeutic perspectives for ACh and its receptors.

Muscarinic receptors and cancer: possible implication in tumor of the nervous system / Tata, Ada Maria; Calogero, Antonella. - In: CURRENT TRENDS IN NEUROLOGY. - ISSN 0972-8252. - STAMPA. - 4:(2010), pp. 23-31.

Muscarinic receptors and cancer: possible implication in tumor of the nervous system.

TATA, Ada Maria;CALOGERO, ANTONELLA
2010

Abstract

Muscarinic receptors are expressed in several primary and metastatic tumours. In some of these, acetylcholine synthesized by the tumour cells through autocrine mechanism often mediated by muscarinic receptors, can contribute to tumour progression, modulating cell proliferation, survival, migration and angiogenesis. Acetylcholine also appears to be involved in brain tumours. In fact, patients with these pathologies show altered levels of ACh in their cerebrospinal fluid. Astrocytomas, glioblastomas and neuroblastomas express both nicotinic and muscarinic receptors, and their activation enhances different signal transduction pathways involving AKT, PIK3, MAPK and ERK. The present review is focused on recent studies demonstrating the muscarinic receptor involvement in the modulation of proliferation, survival and migration in tumours of the central and peripheral nervous system. These data together with observations reported for other pathologies, open up new interesting therapeutic perspectives for ACh and its receptors.
2010
muscarinic receptors; acetylcholine; astocytoma; glioblastoma neuroblastoma
01 Pubblicazione su rivista::01a Articolo in rivista
Muscarinic receptors and cancer: possible implication in tumor of the nervous system / Tata, Ada Maria; Calogero, Antonella. - In: CURRENT TRENDS IN NEUROLOGY. - ISSN 0972-8252. - STAMPA. - 4:(2010), pp. 23-31.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/229581
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact