In patients with distal symmetric polyneuropathy we assessed non-nociceptive Aβ- and nociceptive Aδ-afferents to investigate their role in the development of neuropathic pain. We screened 2240 consecutive patients with sensory disturbances and collected 150 patients with distal symmetric polyneuropathy (68 with pain and 82 without). All patients underwent the Neuropathic Pain Symptom Inventory to rate ongoing, paroxysmal and provoked pains, a standard nerve conduction study (NCS) to assess Aβ-fibre function, and laser-evoked potentials (LEPs) to assess Aδ-fibre function. Patients with pain had the same age (P > 0.50), but a longer delay since symptom onset than those without (P < 0.01). Whereas the LEP amplitude was significantly lower in patients with pain than in those without (P < 0.0001), NCS data did not differ between groups (P > 0.50). LEPs were more severely affected in patients with ongoing pain than in those with provoked pain (P < 0.0001). Our findings indicate that the impairment of Aβ-fibres has no role in the development of ongoing or provoked pain. In patients with ongoing pain the severe LEP suppression and the correlation between pain intensity and LEP attenuation may indicate that this type of pain reflects damage to nociceptive axons. The partially preserved LEPs in patients with provoked pain suggest that this type of pain is related to the abnormal activity arising from partially spared and sensitised nociceptive terminals. Because clinical and neurophysiological abnormalities followed similar patterns regardless of aetiology, pain should be classified and treated on mechanism-based grounds. © 2010 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

Mechanisms of pain in distal symmetric polyneuropathy: A combined clinical and neurophysiological study / Truini, Andrea; Biasiotta, Antonella; LA CESA, Silvia; DI STEFANO, Giulia; Galeotti, Francesca; M. T., Petrucci; Inghilleri, Maurizio; C., Cartoni; Pergolini, Mario Sergio; Cruccu, Giorgio. - In: PAIN. - ISSN 0304-3959. - 150:3(2010), pp. 516-521. [10.1016/j.pain.2010.06.006]

Mechanisms of pain in distal symmetric polyneuropathy: A combined clinical and neurophysiological study

TRUINI, ANDREA;BIASIOTTA, ANTONELLA;LA CESA, SILVIA;DI STEFANO, GIULIA;GALEOTTI, FRANCESCA;INGHILLERI, Maurizio;PERGOLINI, Mario Sergio;CRUCCU, Giorgio
2010

Abstract

In patients with distal symmetric polyneuropathy we assessed non-nociceptive Aβ- and nociceptive Aδ-afferents to investigate their role in the development of neuropathic pain. We screened 2240 consecutive patients with sensory disturbances and collected 150 patients with distal symmetric polyneuropathy (68 with pain and 82 without). All patients underwent the Neuropathic Pain Symptom Inventory to rate ongoing, paroxysmal and provoked pains, a standard nerve conduction study (NCS) to assess Aβ-fibre function, and laser-evoked potentials (LEPs) to assess Aδ-fibre function. Patients with pain had the same age (P > 0.50), but a longer delay since symptom onset than those without (P < 0.01). Whereas the LEP amplitude was significantly lower in patients with pain than in those without (P < 0.0001), NCS data did not differ between groups (P > 0.50). LEPs were more severely affected in patients with ongoing pain than in those with provoked pain (P < 0.0001). Our findings indicate that the impairment of Aβ-fibres has no role in the development of ongoing or provoked pain. In patients with ongoing pain the severe LEP suppression and the correlation between pain intensity and LEP attenuation may indicate that this type of pain reflects damage to nociceptive axons. The partially preserved LEPs in patients with provoked pain suggest that this type of pain is related to the abnormal activity arising from partially spared and sensitised nociceptive terminals. Because clinical and neurophysiological abnormalities followed similar patterns regardless of aetiology, pain should be classified and treated on mechanism-based grounds. © 2010 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
2010
laser-evoked potentials; nerve conduction study; neuropathic pain; pain questionnaire; peripheral neuropathy
01 Pubblicazione su rivista::01a Articolo in rivista
Mechanisms of pain in distal symmetric polyneuropathy: A combined clinical and neurophysiological study / Truini, Andrea; Biasiotta, Antonella; LA CESA, Silvia; DI STEFANO, Giulia; Galeotti, Francesca; M. T., Petrucci; Inghilleri, Maurizio; C., Cartoni; Pergolini, Mario Sergio; Cruccu, Giorgio. - In: PAIN. - ISSN 0304-3959. - 150:3(2010), pp. 516-521. [10.1016/j.pain.2010.06.006]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/229147
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