Arterial hypertension represents one of the most common conditions associated with an increased cardiovascular risk. New evidences support the need to adopt a global approach to the treatment of cardiovascular risk in hypertensive subjects by using drugs with proven benefits, not only for blood pressure control, but also for their pleiotropic effects. A greater understanding of the pathogenetic mechanisms of hypertension would provide a better strategy for preventing and treating this condition. Angiotensin II seems to be responsible for triggering vascular inflammation by inducing oxidative stress, resulting in up-regulation of pro-inflammatory mediators that lead to endothelial dysfunction and vascular injury. The interaction of angiotensin II, oxidative stress and endothelial dysfunction might be a target of a new integrated approach with important clinical implications.

Arterial hypertension and cardiovascular risk: need for a combined strategy of intervention / Paoletti, Vincenzo; Raparelli, Valeria; Ferroni, Patrizia; Scarno, Antongiulio; Trinchieri, Fabio; Basili, Stefania; G., Davi. - In: LA CLINICA TERAPEUTICA. - ISSN 0009-9074. - 159:(2008), pp. 269-273.

Arterial hypertension and cardiovascular risk: need for a combined strategy of intervention

PAOLETTI, Vincenzo;RAPARELLI, Valeria;FERRONI, Patrizia;SCARNO, Antongiulio;TRINCHIERI, FABIO;BASILI, Stefania;
2008

Abstract

Arterial hypertension represents one of the most common conditions associated with an increased cardiovascular risk. New evidences support the need to adopt a global approach to the treatment of cardiovascular risk in hypertensive subjects by using drugs with proven benefits, not only for blood pressure control, but also for their pleiotropic effects. A greater understanding of the pathogenetic mechanisms of hypertension would provide a better strategy for preventing and treating this condition. Angiotensin II seems to be responsible for triggering vascular inflammation by inducing oxidative stress, resulting in up-regulation of pro-inflammatory mediators that lead to endothelial dysfunction and vascular injury. The interaction of angiotensin II, oxidative stress and endothelial dysfunction might be a target of a new integrated approach with important clinical implications.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/229016
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