In recent years biodegradable polymers have been used as controlled protein release systems with the aim to develop a singledose vaccine. Poly(l-lactide) single crystals were prepared from a dilute solution and functionalized by surface aminolysis reaction with multifunctional amine. The E7 protein of the Human Papillomavirus 16 (HPV16) was adsorbed, as a model protein, onto aminolyzed lamellar surface to test the crystals as a suitable polymer carrier.
Functionalized poly(l-lactide) single crystals coated with antigens in development of vaccines / G., Casini; L., Petrone; A., Bakry; Francolini, Iolanda; P., Di Bonito; C., Giorgi; Martinelli, Andrea; Piozzi, Antonella; D'Ilario, Lucio. - In: JOURNAL OF CONTROLLED RELEASE. - ISSN 0168-3659. - STAMPA. - 148:1(2010), pp. e106-108. [10.1016/j.jconrel.2010.07.080]
Functionalized poly(l-lactide) single crystals coated with antigens in development of vaccines.
FRANCOLINI, IOLANDA;MARTINELLI, Andrea;PIOZZI, Antonella;D'ILARIO, LUCIO
2010
Abstract
In recent years biodegradable polymers have been used as controlled protein release systems with the aim to develop a singledose vaccine. Poly(l-lactide) single crystals were prepared from a dilute solution and functionalized by surface aminolysis reaction with multifunctional amine. The E7 protein of the Human Papillomavirus 16 (HPV16) was adsorbed, as a model protein, onto aminolyzed lamellar surface to test the crystals as a suitable polymer carrier.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
