Fas and Fas ligand (FasL), members of the tumor necrosis factor (TNF) and TNF-receptor (TNFR) families of molecules, are involved in apoptosis. They are expressed in membrane-associated as well as soluble forms (sFas, and sFasL). Apoptotic defects underlie some models of autoimmune diseases, and they have been proposed in the pathogenesis of systemic lupus erythematosus (SLE) a prototypic autoimmune disorder. We measured the serum levels of sFas and sFasL in a series of well characterized SLE patients and devised an index of the two forms which resulted to be associated with age, indicating that apoptosis resistance is modulated during aging, thus explaining the conflicting observations made in previous studies.
SERUM sFas/sFasL RATIO IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) IS A FUNCTION OF AGE / M. C., Turi; M., D'Urbano; E., Celletti; Alessandri, Cristiano; Valesini, Guido; R., Paganelli. - In: ARCHIVES OF GERONTOLOGY AND GERIATRICS. - ISSN 0167-4943. - STAMPA. - 49:(2009), pp. 221-226. [10.1016/j.archger.2009.09.032]
SERUM sFas/sFasL RATIO IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) IS A FUNCTION OF AGE
ALESSANDRI, cristiano;VALESINI, Guido;
2009
Abstract
Fas and Fas ligand (FasL), members of the tumor necrosis factor (TNF) and TNF-receptor (TNFR) families of molecules, are involved in apoptosis. They are expressed in membrane-associated as well as soluble forms (sFas, and sFasL). Apoptotic defects underlie some models of autoimmune diseases, and they have been proposed in the pathogenesis of systemic lupus erythematosus (SLE) a prototypic autoimmune disorder. We measured the serum levels of sFas and sFasL in a series of well characterized SLE patients and devised an index of the two forms which resulted to be associated with age, indicating that apoptosis resistance is modulated during aging, thus explaining the conflicting observations made in previous studies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
