A variety of functionalities, including the whole range of halogen substituents, are tolerated in the title reaction, an intramolecular approach for the construction of a multisubstituted indole skeleton from readily available enaminones (see scheme; phen=1,10-phenanthroline). The indole products are also prepared directly in high yield from a,b-ynones and primary amines.
Copper-Catalyzed C-C Bond Formation via C-H Functionalization: Synthesis of Multisubstituted Indoles from N-(Aryl)enaminones / Bernini, R; Fabrizi, Giancarlo; Sferrazza, Alessio; Cacchi, Sandro. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 48:(2009), pp. 8078-8081. [10.1002/anie.200902440]
Copper-Catalyzed C-C Bond Formation via C-H Functionalization: Synthesis of Multisubstituted Indoles from N-(Aryl)enaminones
FABRIZI, Giancarlo;SFERRAZZA, ALESSIO;CACCHI, Sandro
2009
Abstract
A variety of functionalities, including the whole range of halogen substituents, are tolerated in the title reaction, an intramolecular approach for the construction of a multisubstituted indole skeleton from readily available enaminones (see scheme; phen=1,10-phenanthroline). The indole products are also prepared directly in high yield from a,b-ynones and primary amines.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
