A new, green and efficient strategy for the synthesis of trifluoromethyl ketimines, aldimines, and hydrazones starting from the corresponding trifluoromethyl carbonyl compounds or their hemiacetals is reported. The condensation reactions were performed under solvent-free conditions with a range of amines or hydrazines and proceeded with high stereoselectivity, always giving only the E-isomer in very good yields.
Solvent-Free Stereoselective Synthesis of (E)-Trifluoromethyl Imines and Hydrazones / Laura, Carroccia; Fioravanti, Stefania; Pellacani, Lucio; Tardella, Paolo Antonio. - In: SYNTHESIS. - ISSN 0039-7881. - STAMPA. - 2010:23(2010), pp. 4096-4100. [10.1055/s-0030-1258280]
Solvent-Free Stereoselective Synthesis of (E)-Trifluoromethyl Imines and Hydrazones
FIORAVANTI, Stefania;PELLACANI, Lucio;TARDELLA, Paolo Antonio
2010
Abstract
A new, green and efficient strategy for the synthesis of trifluoromethyl ketimines, aldimines, and hydrazones starting from the corresponding trifluoromethyl carbonyl compounds or their hemiacetals is reported. The condensation reactions were performed under solvent-free conditions with a range of amines or hydrazines and proceeded with high stereoselectivity, always giving only the E-isomer in very good yields.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
