The effects of five antibiotics, previously described as ligands of protein disulfide isomerase PDI, have now been studied on the homologous protein ERp57. They bind to this protein with much higher affinity than to PDI, and some of them inhibit the reductase and the DNA-binding activities of ERp57. In view of the high affinity of vancomycin, erythromycin and streptomycin, some effects of their interaction with this protein might be expected in vivo.

The binding of antibiotics to ERp57/GRP58 / Elisa, Gaucci; Chichiarelli, Silvia; Grillo, Caterina; E., Del Vecchio; Eufemi, Margherita; Turano, Carlo. - In: JOURNAL OF ANTIBIOTICS. - ISSN 0021-8820. - 61:6(2008), pp. 400-402. [10.1038/ja.2008.56]

The binding of antibiotics to ERp57/GRP58

CHICHIARELLI, Silvia;GRILLO, CATERINA;EUFEMI, Margherita;TURANO, Carlo
2008

Abstract

The effects of five antibiotics, previously described as ligands of protein disulfide isomerase PDI, have now been studied on the homologous protein ERp57. They bind to this protein with much higher affinity than to PDI, and some of them inhibit the reductase and the DNA-binding activities of ERp57. In view of the high affinity of vancomycin, erythromycin and streptomycin, some effects of their interaction with this protein might be expected in vivo.
2008
aminoglycoside antibiotics; erp57/grp58; erythromycin; vancomycin
01 Pubblicazione su rivista::01a Articolo in rivista
The binding of antibiotics to ERp57/GRP58 / Elisa, Gaucci; Chichiarelli, Silvia; Grillo, Caterina; E., Del Vecchio; Eufemi, Margherita; Turano, Carlo. - In: JOURNAL OF ANTIBIOTICS. - ISSN 0021-8820. - 61:6(2008), pp. 400-402. [10.1038/ja.2008.56]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/226899
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