C-kit is expressed in almost all GISTs, and the tumorigenesis of GISTs (which are mesenchymal tumors) involves mutations resulting in constitutive activation of tyrosine kinase receptor c-kit. It should be interesting to investigate the possible relationships between c-kit and EGF-R expression and EMT that occurs during neoplastic progression in the epithelial cancer cells in the bulk tumor, at the tumor invasion front, and in regional nodal and distant metastasis of colorectal carcinomas. The variability in EMT markers expression have been recently showed in neoplastic cells of these different topographic sites of the same tumor with occurrence of a reverting mesenchymal– epithelial transition (MET) and re-expression of epithelial phenotype in neoplastic cells during metastatic seeding .

Expression of receptors tyrosine kinase c-kit and EGF-R in colorectal adenocarcinomas: is there a relationship with epithelial-mesenchymal transition during tumor progression? / Peparini, Nadia; Caronna, Roberto; Tellan, Guglielmo; Chirletti, Piero. - In: LANGENBECK'S ARCHIVES OF SURGERY. - ISSN 1435-2443. - 394 (6):(2009), pp. 1131-1132. [10.1007/s00423-009-0513-9]

Expression of receptors tyrosine kinase c-kit and EGF-R in colorectal adenocarcinomas: is there a relationship with epithelial-mesenchymal transition during tumor progression?

PEPARINI, Nadia;CARONNA, Roberto;TELLAN, Guglielmo;CHIRLETTI, Piero
2009

Abstract

C-kit is expressed in almost all GISTs, and the tumorigenesis of GISTs (which are mesenchymal tumors) involves mutations resulting in constitutive activation of tyrosine kinase receptor c-kit. It should be interesting to investigate the possible relationships between c-kit and EGF-R expression and EMT that occurs during neoplastic progression in the epithelial cancer cells in the bulk tumor, at the tumor invasion front, and in regional nodal and distant metastasis of colorectal carcinomas. The variability in EMT markers expression have been recently showed in neoplastic cells of these different topographic sites of the same tumor with occurrence of a reverting mesenchymal– epithelial transition (MET) and re-expression of epithelial phenotype in neoplastic cells during metastatic seeding .
2009
01 Pubblicazione su rivista::01a Articolo in rivista
Expression of receptors tyrosine kinase c-kit and EGF-R in colorectal adenocarcinomas: is there a relationship with epithelial-mesenchymal transition during tumor progression? / Peparini, Nadia; Caronna, Roberto; Tellan, Guglielmo; Chirletti, Piero. - In: LANGENBECK'S ARCHIVES OF SURGERY. - ISSN 1435-2443. - 394 (6):(2009), pp. 1131-1132. [10.1007/s00423-009-0513-9]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/226596
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