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A new series of 1,5- and 2,5-disubstituted tetrazoles have been synthesized and evaluated as inhibitors of anandamide cellular uptake. Some of them inhibit the uptake process with a relatively high potency (IC50 = 2.3-5.1 μM) and selectively over other proteins involved in endocannabinoid action and metabolism. © 2008 Elsevier Ltd. All rights reserved.

New tetrazole-based selective anandamide uptake inhibitors / Ortar, Giorgio; Aniello Schiano, Moriello; Maria Grazia, Cascio; Luciano De, Petrocellis; Alessia, Ligresti; Morera, Enrico; Nalli, Marianna; Vincenzo Di, Marzo. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 18:9(2008), pp. 2820-2824. [10.1016/j.bmcl.2008.04.003]

New tetrazole-based selective anandamide uptake inhibitors

ORTAR, Giorgio;MORERA, ENRICO;NALLI, Marianna;
2008

Abstract

A new series of 1,5- and 2,5-disubstituted tetrazoles have been synthesized and evaluated as inhibitors of anandamide cellular uptake. Some of them inhibit the uptake process with a relatively high potency (IC50 = 2.3-5.1 μM) and selectively over other proteins involved in endocannabinoid action and metabolism. © 2008 Elsevier Ltd. All rights reserved.
2008
anandamide uptake; anandamide uptake inhibitors; endocannabinoids; tetrazoles
01 Pubblicazione su rivista::01a Articolo in rivista
New tetrazole-based selective anandamide uptake inhibitors / Ortar, Giorgio; Aniello Schiano, Moriello; Maria Grazia, Cascio; Luciano De, Petrocellis; Alessia, Ligresti; Morera, Enrico; Nalli, Marianna; Vincenzo Di, Marzo. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 18:9(2008), pp. 2820-2824. [10.1016/j.bmcl.2008.04.003]
01a Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/226124
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