OBJECTIVE: Previous reports showed the reduction of dopamine transporter immunoreactivity in peripheral blood lymphocytes in Parkinson's disease. In this work, we sought to investigate the possible correlation between central and peripheral dopamine transporter immunoreactivity values in a group of 11 drug-naive patients with Parkinson's disease. METHODS: Densitometric measurements of dopamine transporter immunoreactivity in peripheral blood lymphocytes was accomplished as described recently, using a monoclonal antidopamine transporter antibody. Dopamine transporter binding in the caudate and putamen nuclei was measured by means of (123)I-fluopane single-photon emission computed tomography in the same patients. RESULTS: The results failed to show any significant correlation between dopamine transporter immunoreactivity in peripheral blood lymphocytes and the caudate or putamen dopamine transporter binding. Moreover, dopamine transporter immunoreactivity in peripheral blood lymphocytes was reduced also in the single patient with normal striatal dopamine transporter binding. DISCUSSION: These results indicate the lack of correlation between central and peripheral dopamine transporter reduction in Parkinson's disease, using the methodologies applied herein. They therefore suggest that the two phenomena are unlikely to share a common pathogenetic mechanism.

Central and peripheral dopamine transporter reduction in Parkinson's disease / Buttarelli, Francesca Romana; Capriotti, Gabriela; Pellicano, Clelia; Daniela, Prosperi; Circella, Annapia; Anna, Festa; Morena, Giovannelli; Anna, Tofani; Pontieri, FRANCESCO ERNESTO; Scopinaro, Francesco. - In: NEUROLOGICAL RESEARCH. - ISSN 0161-6412. - 31:7(2009), pp. 687-691. [10.1179/174313209x383259]

Central and peripheral dopamine transporter reduction in Parkinson's disease

BUTTARELLI, Francesca Romana;CAPRIOTTI, Gabriela;PELLICANO, CLELIA;CIRCELLA, annapia;PONTIERI, FRANCESCO ERNESTO;SCOPINARO, Francesco
2009

Abstract

OBJECTIVE: Previous reports showed the reduction of dopamine transporter immunoreactivity in peripheral blood lymphocytes in Parkinson's disease. In this work, we sought to investigate the possible correlation between central and peripheral dopamine transporter immunoreactivity values in a group of 11 drug-naive patients with Parkinson's disease. METHODS: Densitometric measurements of dopamine transporter immunoreactivity in peripheral blood lymphocytes was accomplished as described recently, using a monoclonal antidopamine transporter antibody. Dopamine transporter binding in the caudate and putamen nuclei was measured by means of (123)I-fluopane single-photon emission computed tomography in the same patients. RESULTS: The results failed to show any significant correlation between dopamine transporter immunoreactivity in peripheral blood lymphocytes and the caudate or putamen dopamine transporter binding. Moreover, dopamine transporter immunoreactivity in peripheral blood lymphocytes was reduced also in the single patient with normal striatal dopamine transporter binding. DISCUSSION: These results indicate the lack of correlation between central and peripheral dopamine transporter reduction in Parkinson's disease, using the methodologies applied herein. They therefore suggest that the two phenomena are unlikely to share a common pathogenetic mechanism.
2009
dopamine transporter; immunocytochemistry; parkinson's disease; peripheral blood lymphocytes; single-photon emission computed tomography
01 Pubblicazione su rivista::01a Articolo in rivista
Central and peripheral dopamine transporter reduction in Parkinson's disease / Buttarelli, Francesca Romana; Capriotti, Gabriela; Pellicano, Clelia; Daniela, Prosperi; Circella, Annapia; Anna, Festa; Morena, Giovannelli; Anna, Tofani; Pontieri, FRANCESCO ERNESTO; Scopinaro, Francesco. - In: NEUROLOGICAL RESEARCH. - ISSN 0161-6412. - 31:7(2009), pp. 687-691. [10.1179/174313209x383259]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/225785
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