Self-assembling gelling peptides are increasingly being investigated as defined biomatrices for biomedical applications. Using an enzymatic reaction to convert a precursor into a hydrogelator one can control or modulate functions and responses of a hydrogel, depending on its preparation conditions. This work details the self-assembly, under physiological conditions, of amphiphilic building blocks consisting of tripeptides (Phe(3)) linked to fluorenylmethoxycarbonyl (Fmoc) obtained by using a lipase to link an Fmoc-Phe amino acid to the dipeptide diphenylalanine (Phe(2)). The viscoelastic properties of the tripeptides obtained were investigated. SEM and AFM images of Fmoc- peptides confirmed that they self-assemble to generate supramolecular aggregates driven by pi-pi stacking interactions of the Fmoc groups.
Lipase-supported synthesis of peptidic hydrogels / Chronopoulou, Laura; Silvia, Lorenzoni; Masci, Giancarlo; Dentini, Mariella; Togna, Anna Rita; Togna, Giuseppina Ines; Bordi, Federico; Palocci, Cleofe. - In: SOFT MATTER. - ISSN 1744-683X. - STAMPA. - 6:11(2010), pp. 2525-2532. [10.1039/c001658f]
Lipase-supported synthesis of peptidic hydrogels
CHRONOPOULOU, LAURA;MASCI, Giancarlo;DENTINI, Mariella;TOGNA, Anna Rita;TOGNA, Giuseppina Ines;BORDI, FEDERICO;PALOCCI, Cleofe
2010
Abstract
Self-assembling gelling peptides are increasingly being investigated as defined biomatrices for biomedical applications. Using an enzymatic reaction to convert a precursor into a hydrogelator one can control or modulate functions and responses of a hydrogel, depending on its preparation conditions. This work details the self-assembly, under physiological conditions, of amphiphilic building blocks consisting of tripeptides (Phe(3)) linked to fluorenylmethoxycarbonyl (Fmoc) obtained by using a lipase to link an Fmoc-Phe amino acid to the dipeptide diphenylalanine (Phe(2)). The viscoelastic properties of the tripeptides obtained were investigated. SEM and AFM images of Fmoc- peptides confirmed that they self-assemble to generate supramolecular aggregates driven by pi-pi stacking interactions of the Fmoc groups.File | Dimensione | Formato | |
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