Starting from a library of 2-L-alpha-amino acyl (E)-acrylonitriles, different short 2-cyano and 2-amino aziridinyl peptides, potential protease inhibitors. were obtained under parallel solution-phase conditions. The transformations include careful selection of conditions for aziridine deprotection and cyano group partial hydrolysis. (c) 2008 Elsevier Ltd. All rights reserved.
Solution-phase synthesis of 2-cyano and 2-amido aziridinyl peptides / Fioravanti, Stefania; Davide, Massari; Morreale, Alberto; Pellacani, Lucio; Tardella, Paolo Antonio. - In: TETRAHEDRON. - ISSN 0040-4020. - STAMPA. - 64:14(2008), pp. 3204-3211. [10.1016/j.tet.2008.01.098]
Solution-phase synthesis of 2-cyano and 2-amido aziridinyl peptides
FIORAVANTI, Stefania;MORREALE, Alberto;PELLACANI, Lucio;TARDELLA, Paolo Antonio
2008
Abstract
Starting from a library of 2-L-alpha-amino acyl (E)-acrylonitriles, different short 2-cyano and 2-amino aziridinyl peptides, potential protease inhibitors. were obtained under parallel solution-phase conditions. The transformations include careful selection of conditions for aziridine deprotection and cyano group partial hydrolysis. (c) 2008 Elsevier Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
