Starting from a library of 2-L-alpha-amino acyl (E)-acrylonitriles, different short 2-cyano and 2-amino aziridinyl peptides, potential protease inhibitors. were obtained under parallel solution-phase conditions. The transformations include careful selection of conditions for aziridine deprotection and cyano group partial hydrolysis. (c) 2008 Elsevier Ltd. All rights reserved.
Solution-phase synthesis of 2-cyano and 2-amido aziridinyl peptides / Fioravanti, S., Davide, M., Morreale, A., Pellacani, L., Tardella, P.A.. - In: TETRAHEDRON. - ISSN 0040-4020. - STAMPA. - 64:14(2008), pp. 3204-3211. [10.1016/j.tet.2008.01.098]
Solution-phase synthesis of 2-cyano and 2-amido aziridinyl peptides
FIORAVANTI, Stefania;MORREALE, Alberto;PELLACANI, Lucio;TARDELLA, Paolo Antonio
2008
Abstract
Starting from a library of 2-L-alpha-amino acyl (E)-acrylonitriles, different short 2-cyano and 2-amino aziridinyl peptides, potential protease inhibitors. were obtained under parallel solution-phase conditions. The transformations include careful selection of conditions for aziridine deprotection and cyano group partial hydrolysis. (c) 2008 Elsevier Ltd. All rights reserved.File allegati a questo prodotto
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
