N-substituted-3-carboxamido-coumarin derivatives were prepared and evaluated for selective antibacterial activity against 20 isolates of Helicobacter pylori clinical strains, including five metronidazole resistant ones. Some of them possessed the best activity against H. pylori metronidazole resistant strains with MIC values lower than the drug reference (metronidazole). Furthermore, anti-inflammatory activity through the inhibition of the IL-8 production was investigated. (c) 2010 Elsevier Ltd. All rights reserved.
Synthesis, selective anti-Helicobacter pylori activity, and cytotoxicity of novel N-substituted-2-oxo-2H-1-benzopyran-3-carboxamides / Chimenti, Franco; Bizzarri, Bruna; Bolasco, Adriana; Secci, Daniela; Chimenti, Paola; Granese, Arianna; Carradori, Simone; Rivanera, Daniela; Zicari, Alessandra; M., Maddalena Scaltrito; Francesca, Sisto. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - STAMPA. - 20:16(2010), pp. 4922-4926. [10.1016/j.bmcl.2010.06.048]
Synthesis, selective anti-Helicobacter pylori activity, and cytotoxicity of novel N-substituted-2-oxo-2H-1-benzopyran-3-carboxamides
CHIMENTI, Franco;BIZZARRI, Bruna;BOLASCO, Adriana;SECCI, DANIELA;CHIMENTI, Paola;GRANESE, ARIANNA;CARRADORI, Simone;RIVANERA, Daniela;ZICARI, Alessandra;
2010
Abstract
N-substituted-3-carboxamido-coumarin derivatives were prepared and evaluated for selective antibacterial activity against 20 isolates of Helicobacter pylori clinical strains, including five metronidazole resistant ones. Some of them possessed the best activity against H. pylori metronidazole resistant strains with MIC values lower than the drug reference (metronidazole). Furthermore, anti-inflammatory activity through the inhibition of the IL-8 production was investigated. (c) 2010 Elsevier Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
